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- W2006780016 abstract "Dopaminergic neurons that innervate the region of the nucleus accumbens are important substrates for the reinforcing properties of stimulant drugs such as cocaine and damphetamine. This raises questions regarding the normal functions of these neurons in motivated behaviors. A review of recent data, obtained primarily with in vivo brain microdialysis, indicates that dopamine release is enhanced in the nucleus accumbens primarily during the performance of consummatory, as opposed to preparatory, components of motivated behavior. As neuroleptic drugs are competitive dopamine receptor antagonists, the results of these microdialysis experiments may provide a neurochemical framework within which to understand the selective effects of low doses of neuroleptics on preparatory behaviors. Specifically, the hypothesis is advanced that consummatory behaviors are more resistant to the disruptive effects of neuroleptics because the enhanced dopamine release that occurs during the performance of these behaviors is sufficient to overcome the level of postsynaptic dopamine receptor blockade that prevents the expression of preparatory behaviors." @default.
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- W2006780016 date "1993-10-01" @default.
- W2006780016 modified "2023-10-03" @default.
- W2006780016 title "Mesolimbic dopamine: An analysis of its role in motivated behavior" @default.
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- W2006780016 doi "https://doi.org/10.1016/s1044-5765(05)80039-9" @default.
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