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- W2006783622 abstract "The tritiated loop diuretic, piretanide, is a useful ligand for specific diuretic receptors which are present in the plasma membranes of renal medullary cells. Its high specific activity (30 Ci X mmol-1) made it possible to demonstrate the existence of a high affinity receptor (Kd approximately 5 nM) and a binding site with low affinity. High affinity binding is saturable, reversible and displaceable by a number of non-radioactive loop diuretics. Structural analogues, devoid of diuretic activity, do not displace piretanide binding. No specific binding occurs in liver or spleen membranes." @default.
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- W2006783622 date "1985-08-01" @default.
- W2006783622 modified "2023-10-14" @default.
- W2006783622 title "Characterization of a high affinity piretanide receptor on kidney membranes" @default.
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- W2006783622 doi "https://doi.org/10.1016/0014-2999(85)90516-3" @default.
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