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• W2006783928 abstract "The major inhibitory neurotransmitters GABA and glycine provide the bulk of input to large-field ganglion cells in the retina. Whole-cell patch-clamp recordings were used to characterize the glycine- and GABA-activated currents for morphologically identified ON-alpha ganglion cells in the rabbit retina. Cells identified as ON-alpha cells by light evoked currents were intracellularly stained and examined by light microscopy which revealed dendritic stratification in the vitreal half of the inner plexiform layer and confirmed their physiological identity. All Ca(2+)-mediated synaptic influences were abolished with Co(2+), revealing two types of ON-alpha cell characterized by their different inhibitory current profiles. One group exhibited larger glycine- than GABA-activated currents, while the other group had larger GABA- than glycine-activated currents. Both cell types demonstrated strychnine-sensitive glycine-activated currents and bicuculline-sensitive GABAA-activated currents. Surprisingly, both cell types expressed functional GABAC receptors demonstrated by their sensitivity to TPMPA. In addition, the cells with larger glycine-activated currents also possessed GABAB receptors, whereas those with larger GABA-activated currents did not. Immunocytochemical experiments confirmed the presence of glycine, GABAA, and GABAC receptor subunits on all physiologically identified ON-alpha ganglion cells in this study. In addition, the GABAB receptor immunolabeled puncta were present on the cells with larger glycine-activated currents, but not on the cells with the larger GABA-activated currents. In conclusion, the presence of different functional GABA and glycine receptors determined physiologically correlated well with the specific GABA and glycine receptor immunolabeling for two neuropharmacological types of rabbit ON-alpha ganglion cells." @default.
• W2006783928 created "2016-06-24" @default.
• W2006783928 creator A5012032028 @default.
• W2006783928 creator A5080742339 @default.
• W2006783928 date "2003-07-01" @default.
• W2006783928 modified "2023-10-04" @default.
• W2006783928 title "Two neuropharmacological types of rabbit ON-alpha ganglion cells express GABA_C receptors" @default.
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• W2006783928 doi "https://doi.org/10.1017/s095252380320403x" @default.
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• W2006783928 hasPublicationYear "2003" @default.
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