FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006788557> ?p ?o ?g. }

• W2006788557 endingPage "198" @default.
• W2006788557 startingPage "192" @default.
• W2006788557 abstract "P450BM-3, a catalytically self-sufficient, soluble bacterial P450, contains on the same polypeptide a heme domain and a reductase domain. P450BM-3 catalyzes the oxidation of short- and long-chain, saturated and unsaturated fatty acids. The three-dimensional structure of the heme domain both in the absence and in the presence of fatty acid substrates has been determined; however, the fatty acid in the substrate-bound form is not adequately close to the heme iron to permit a prediction regarding the stereoselectivity of oxidation. In the case of long-chain fatty acids, the products can also serve as substrate and be metabolized several times. In the current study, we have determined the absolute configuration of the three primary products of palmitic acid hydroxylation (15-, 14-, and 13-OH palmitic acid). While the 15- and 14-hydroxy compounds are produced in a highly stereoselective manner (98% R, 2% S), the 13-hydroxy is a mixture of 72% R and 28% S. We have also examined the binding of these three hydroxy acids to P450BM-3 and shown that only two of them (14-OH and 13-OH palmitic acid) can bind to and be further metabolized by P450BM-3. The results indicate that in contrast to the flexibility of palmitoleic acid bound to the oxidized enzyme, palmitic acid is rigidly bound in the active site during catalytic turnover." @default.
• W2006788557 created "2016-06-24" @default.
• W2006788557 creator A5043458164 @default.
• W2006788557 creator A5044887967 @default.
• W2006788557 creator A5077198825 @default.
• W2006788557 creator A5079472111 @default.
• W2006788557 date "1999-06-01" @default.
• W2006788557 modified "2023-10-05" @default.
• W2006788557 title "P450BM-3: Absolute Configuration of the Primary Metabolites of Palmitic Acid" @default.
• W2006788557 cites W1492141962 @default.
• W2006788557 cites W1515424959 @default.
• W2006788557 cites W1554781559 @default.
• W2006788557 cites W1574035164 @default.
• W2006788557 cites W1595089190 @default.
• W2006788557 cites W1605985146 @default.
• W2006788557 cites W1980420922 @default.
• W2006788557 cites W1989272963 @default.
• W2006788557 cites W1998252754 @default.
• W2006788557 cites W2000051743 @default.
• W2006788557 cites W2004201056 @default.
• W2006788557 cites W2006998778 @default.
• W2006788557 cites W2022471249 @default.
• W2006788557 cites W2031174410 @default.
• W2006788557 cites W2045081422 @default.
• W2006788557 cites W2079003753 @default.
• W2006788557 cites W2122062071 @default.
• W2006788557 cites W2177589052 @default.
• W2006788557 doi "https://doi.org/10.1006/abbi.1999.1156" @default.
• W2006788557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10356283" @default.
• W2006788557 hasPublicationYear "1999" @default.
• W2006788557 type Work @default.
• W2006788557 sameAs 2006788557 @default.
• W2006788557 citedByCount "38" @default.
• W2006788557 countsByYear W20067885572012 @default.
• W2006788557 countsByYear W20067885572013 @default.
• W2006788557 countsByYear W20067885572014 @default.
• W2006788557 countsByYear W20067885572015 @default.
• W2006788557 countsByYear W20067885572016 @default.
• W2006788557 countsByYear W20067885572018 @default.
• W2006788557 countsByYear W20067885572020 @default.
• W2006788557 crossrefType "journal-article" @default.
• W2006788557 hasAuthorship W2006788557A5043458164 @default.
• W2006788557 hasAuthorship W2006788557A5044887967 @default.
• W2006788557 hasAuthorship W2006788557A5077198825 @default.
• W2006788557 hasAuthorship W2006788557A5079472111 @default.
• W2006788557 hasBestOaLocation W20067885571 @default.
• W2006788557 hasConcept C134651460 @default.
• W2006788557 hasConcept C161790260 @default.
• W2006788557 hasConcept C178790620 @default.
• W2006788557 hasConcept C181199279 @default.
• W2006788557 hasConcept C181647583 @default.
• W2006788557 hasConcept C185592680 @default.
• W2006788557 hasConcept C18903297 @default.
• W2006788557 hasConcept C2776217839 @default.
• W2006788557 hasConcept C2777289219 @default.
• W2006788557 hasConcept C2779641957 @default.
• W2006788557 hasConcept C2779936771 @default.
• W2006788557 hasConcept C2781109383 @default.
• W2006788557 hasConcept C2911225412 @default.
• W2006788557 hasConcept C543025807 @default.
• W2006788557 hasConcept C55493867 @default.
• W2006788557 hasConcept C71240020 @default.
• W2006788557 hasConcept C86803240 @default.
• W2006788557 hasConceptScore W2006788557C134651460 @default.
• W2006788557 hasConceptScore W2006788557C161790260 @default.
• W2006788557 hasConceptScore W2006788557C178790620 @default.
• W2006788557 hasConceptScore W2006788557C181199279 @default.
• W2006788557 hasConceptScore W2006788557C181647583 @default.
• W2006788557 hasConceptScore W2006788557C185592680 @default.
• W2006788557 hasConceptScore W2006788557C18903297 @default.
• W2006788557 hasConceptScore W2006788557C2776217839 @default.
• W2006788557 hasConceptScore W2006788557C2777289219 @default.
• W2006788557 hasConceptScore W2006788557C2779641957 @default.
• W2006788557 hasConceptScore W2006788557C2779936771 @default.
• W2006788557 hasConceptScore W2006788557C2781109383 @default.
• W2006788557 hasConceptScore W2006788557C2911225412 @default.
• W2006788557 hasConceptScore W2006788557C543025807 @default.
• W2006788557 hasConceptScore W2006788557C55493867 @default.
• W2006788557 hasConceptScore W2006788557C71240020 @default.
• W2006788557 hasConceptScore W2006788557C86803240 @default.
• W2006788557 hasIssue "2" @default.
• W2006788557 hasLocation W20067885571 @default.
• W2006788557 hasLocation W20067885572 @default.
• W2006788557 hasOpenAccess W2006788557 @default.
• W2006788557 hasPrimaryLocation W20067885571 @default.
• W2006788557 hasRelatedWork W1485724614 @default.
• W2006788557 hasRelatedWork W1895500855 @default.
• W2006788557 hasRelatedWork W2006788557 @default.
• W2006788557 hasRelatedWork W2011096607 @default.
• W2006788557 hasRelatedWork W2015853466 @default.
• W2006788557 hasRelatedWork W2025852941 @default.
• W2006788557 hasRelatedWork W2088864691 @default.
• W2006788557 hasRelatedWork W2142850720 @default.
• W2006788557 hasRelatedWork W2531252504 @default.
• W2006788557 hasRelatedWork W3173632723 @default.
• W2006788557 hasVolume "366" @default.
• W2006788557 isParatext "false" @default.
• W2006788557 isRetracted "false" @default.

• next