Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006791806> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2006791806 endingPage "16" @default.
- W2006791806 startingPage "15" @default.
- W2006791806 abstract "Extracellular microRNAs (miRNAs) embedded in circulating exosomes may serves as prognostic biomarkers in cancer.To identify and evaluate plasma exosomal miRNAs for prognosis in castration-resistant prostate cancer (CRPC).RNA sequencing was performed to identify candidate exosomal miRNAs associated with overall survival in a screening cohort of 23 CRPC patients. Candidate miRNAs were further evaluated for prognosis using quantitative real-time polymerase chain reaction in a follow-up cohort of 100 CRPC patients.Cox regression and Kaplan-Meier survival analyses were used to evaluate survival association using candidate miRNAs along with clinical prognostic factors.RNA sequencing in screening cohort generated approximately 6.80 million mappable reads per patient. Of those with normalized read counts ≥5, 43% were mapped to miRNAs for a total of 375 known and 57 novel miRNAs. Cox regression analysis identified an association of miR-1290, -1246, and -375 with overall survival (false discover rate < 0.05). Of those, higher levels of miR-1290 and -375 were significantly associated with poor overall survival (p < 0.004) in the follow-up cohort. Incorporation of miR-1290/-375 into putative clinical prognostic factors-based models in CRPC stage significantly improved predictive performance with a time-dependent area under the curve increase from 0.66 to 0.73 (p = 6.57 × 10−6).Plasma exosomal miR-1290 and miR-375 are promising prognostic biomarkers for CRPC patients. Prospective validation is needed for further evaluation of these candidate miRNAs.In this study, we evaluated whether small RNAs circulating in blood could be used to predict clinical outcomes in late-stage prostate cancer patients. We identified two blood-based small RNAs whose levels showed significant association with survival. Our results warrant further investigation because the noninvasive blood-based test has great potential in the management of late-stage prostate cancer." @default.
- W2006791806 created "2016-06-24" @default.
- W2006791806 creator A5059475139 @default.
- W2006791806 creator A5081165728 @default.
- W2006791806 date "2015-01-01" @default.
- W2006791806 modified "2023-09-27" @default.
- W2006791806 title "Severity of Symptoms of Overactive Bladder: A Predictor of Success and of Failure" @default.
- W2006791806 cites W1921217411 @default.
- W2006791806 cites W2021649310 @default.
- W2006791806 cites W2030602028 @default.
- W2006791806 cites W2051443038 @default.
- W2006791806 cites W2069136115 @default.
- W2006791806 cites W2082043076 @default.
- W2006791806 cites W2082897746 @default.
- W2006791806 cites W2107806473 @default.
- W2006791806 cites W2116324813 @default.
- W2006791806 cites W2147668516 @default.
- W2006791806 doi "https://doi.org/10.1016/j.eururo.2014.07.018" @default.
- W2006791806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25103695" @default.
- W2006791806 hasPublicationYear "2015" @default.
- W2006791806 type Work @default.
- W2006791806 sameAs 2006791806 @default.
- W2006791806 citedByCount "2" @default.
- W2006791806 countsByYear W20067918062015 @default.
- W2006791806 crossrefType "journal-article" @default.
- W2006791806 hasAuthorship W2006791806A5059475139 @default.
- W2006791806 hasAuthorship W2006791806A5081165728 @default.
- W2006791806 hasConcept C104317684 @default.
- W2006791806 hasConcept C10515644 @default.
- W2006791806 hasConcept C121608353 @default.
- W2006791806 hasConcept C126322002 @default.
- W2006791806 hasConcept C143998085 @default.
- W2006791806 hasConcept C145059251 @default.
- W2006791806 hasConcept C188816634 @default.
- W2006791806 hasConcept C20518536 @default.
- W2006791806 hasConcept C2780192828 @default.
- W2006791806 hasConcept C2780352672 @default.
- W2006791806 hasConcept C50382708 @default.
- W2006791806 hasConcept C55493867 @default.
- W2006791806 hasConcept C60644358 @default.
- W2006791806 hasConcept C71924100 @default.
- W2006791806 hasConcept C72563966 @default.
- W2006791806 hasConcept C86803240 @default.
- W2006791806 hasConceptScore W2006791806C104317684 @default.
- W2006791806 hasConceptScore W2006791806C10515644 @default.
- W2006791806 hasConceptScore W2006791806C121608353 @default.
- W2006791806 hasConceptScore W2006791806C126322002 @default.
- W2006791806 hasConceptScore W2006791806C143998085 @default.
- W2006791806 hasConceptScore W2006791806C145059251 @default.
- W2006791806 hasConceptScore W2006791806C188816634 @default.
- W2006791806 hasConceptScore W2006791806C20518536 @default.
- W2006791806 hasConceptScore W2006791806C2780192828 @default.
- W2006791806 hasConceptScore W2006791806C2780352672 @default.
- W2006791806 hasConceptScore W2006791806C50382708 @default.
- W2006791806 hasConceptScore W2006791806C55493867 @default.
- W2006791806 hasConceptScore W2006791806C60644358 @default.
- W2006791806 hasConceptScore W2006791806C71924100 @default.
- W2006791806 hasConceptScore W2006791806C72563966 @default.
- W2006791806 hasConceptScore W2006791806C86803240 @default.
- W2006791806 hasIssue "1" @default.
- W2006791806 hasLocation W20067918061 @default.
- W2006791806 hasLocation W20067918062 @default.
- W2006791806 hasOpenAccess W2006791806 @default.
- W2006791806 hasPrimaryLocation W20067918061 @default.
- W2006791806 hasRelatedWork W1411054225 @default.
- W2006791806 hasRelatedWork W2068396393 @default.
- W2006791806 hasRelatedWork W2135687976 @default.
- W2006791806 hasRelatedWork W2570544313 @default.
- W2006791806 hasRelatedWork W2596040508 @default.
- W2006791806 hasRelatedWork W2962725324 @default.
- W2006791806 hasRelatedWork W3074585435 @default.
- W2006791806 hasRelatedWork W3184068580 @default.
- W2006791806 hasRelatedWork W3187743075 @default.
- W2006791806 hasRelatedWork W4292448967 @default.
- W2006791806 hasVolume "67" @default.
- W2006791806 isParatext "false" @default.
- W2006791806 isRetracted "false" @default.
- W2006791806 magId "2006791806" @default.
- W2006791806 workType "article" @default.