Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006796360> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2006796360 endingPage "249" @default.
- W2006796360 startingPage "241" @default.
- W2006796360 abstract "It was previously speculated that TGFbeta acts as an activator-molecule in chondrogenic pattern formation in the limb micromass culture system, but its precise role and relationship with the cell sorting phenomenon have not been properly studied. In the present study, we examined whether the TGFbeta2 molecule satisfies the necessary conditions for an activator-molecule in the reaction-diffusion model. Firstly, we showed that TGFbeta2 became localized at chondrogenic sites during the establishment of a chondrogenic pattern, and exogenous TGFbeta2 promoted chondrogenesis when added in the culture medium. Secondly, TGFbeta2 protein was shown to promote the production of its own mRNA after 3 hr, indicating that a positive feedback mechanism exists which may be responsible for the emergence of the chondrogenic pattern. We then found that when locally applied with beads, TGFbeta2 suppressed chondrogenesis around the beads, indicating it induces the lateral inhibitory mechanism, which is a key element for the formation of the periodic pattern. We also examined the possible effects of TGFbeta2 on the cell sorting phenomenon and found that TGFbeta2 exerts differential chemotactic activity on proximal and distal mesenchyme cells of the limb bud, and at very early phases of differentiation TGFbeta2 promotes the expression of N-cadherin protein which is known to be involved in pattern formation in this culture system. These findings suggest that TGFbeta2 acts as an activator-like molecule in chondrogenic pattern formation in vitro, and is possibly responsible for the cell sorting phenomenon." @default.
- W2006796360 created "2016-06-24" @default.
- W2006796360 creator A5043070213 @default.
- W2006796360 creator A5055086720 @default.
- W2006796360 date "2000-03-01" @default.
- W2006796360 modified "2023-09-30" @default.
- W2006796360 title "TGF?2 acts as an ?Activator? molecule in reaction-diffusion model and is involved in cell sorting phenomenon in mouse limb micromass culture" @default.
- W2006796360 cites W1503388237 @default.
- W2006796360 cites W1574615823 @default.
- W2006796360 cites W175949082 @default.
- W2006796360 cites W1829679980 @default.
- W2006796360 cites W1842077267 @default.
- W2006796360 cites W1980661496 @default.
- W2006796360 cites W1992963104 @default.
- W2006796360 cites W1997699323 @default.
- W2006796360 cites W2017786515 @default.
- W2006796360 cites W2022073812 @default.
- W2006796360 cites W2026819908 @default.
- W2006796360 cites W2034964406 @default.
- W2006796360 cites W2039129390 @default.
- W2006796360 cites W2046482635 @default.
- W2006796360 cites W2056228425 @default.
- W2006796360 cites W2073933465 @default.
- W2006796360 cites W2081683619 @default.
- W2006796360 cites W2082091542 @default.
- W2006796360 cites W2084294407 @default.
- W2006796360 cites W2086275334 @default.
- W2006796360 cites W2089840306 @default.
- W2006796360 cites W2093837206 @default.
- W2006796360 cites W2100500045 @default.
- W2006796360 cites W2101314011 @default.
- W2006796360 cites W2114154263 @default.
- W2006796360 cites W2133526415 @default.
- W2006796360 cites W2139203676 @default.
- W2006796360 cites W2139983563 @default.
- W2006796360 cites W2172026843 @default.
- W2006796360 cites W4240855764 @default.
- W2006796360 doi "https://doi.org/10.1002/(sici)1097-0177(200003)217:3<241::aid-dvdy2>3.0.co;2-k" @default.
- W2006796360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10741418" @default.
- W2006796360 hasPublicationYear "2000" @default.
- W2006796360 type Work @default.
- W2006796360 sameAs 2006796360 @default.
- W2006796360 citedByCount "107" @default.
- W2006796360 countsByYear W20067963602012 @default.
- W2006796360 countsByYear W20067963602013 @default.
- W2006796360 countsByYear W20067963602014 @default.
- W2006796360 countsByYear W20067963602015 @default.
- W2006796360 countsByYear W20067963602016 @default.
- W2006796360 countsByYear W20067963602017 @default.
- W2006796360 countsByYear W20067963602018 @default.
- W2006796360 countsByYear W20067963602019 @default.
- W2006796360 countsByYear W20067963602020 @default.
- W2006796360 countsByYear W20067963602021 @default.
- W2006796360 countsByYear W20067963602022 @default.
- W2006796360 crossrefType "journal-article" @default.
- W2006796360 hasAuthorship W2006796360A5043070213 @default.
- W2006796360 hasAuthorship W2006796360A5055086720 @default.
- W2006796360 hasBestOaLocation W20067963601 @default.
- W2006796360 hasConcept C104317684 @default.
- W2006796360 hasConcept C185592680 @default.
- W2006796360 hasConcept C198826908 @default.
- W2006796360 hasConcept C2778386714 @default.
- W2006796360 hasConcept C35496256 @default.
- W2006796360 hasConcept C55493867 @default.
- W2006796360 hasConcept C86803240 @default.
- W2006796360 hasConcept C88045685 @default.
- W2006796360 hasConcept C95444343 @default.
- W2006796360 hasConceptScore W2006796360C104317684 @default.
- W2006796360 hasConceptScore W2006796360C185592680 @default.
- W2006796360 hasConceptScore W2006796360C198826908 @default.
- W2006796360 hasConceptScore W2006796360C2778386714 @default.
- W2006796360 hasConceptScore W2006796360C35496256 @default.
- W2006796360 hasConceptScore W2006796360C55493867 @default.
- W2006796360 hasConceptScore W2006796360C86803240 @default.
- W2006796360 hasConceptScore W2006796360C88045685 @default.
- W2006796360 hasConceptScore W2006796360C95444343 @default.
- W2006796360 hasIssue "3" @default.
- W2006796360 hasLocation W20067963601 @default.
- W2006796360 hasLocation W20067963602 @default.
- W2006796360 hasOpenAccess W2006796360 @default.
- W2006796360 hasPrimaryLocation W20067963601 @default.
- W2006796360 hasRelatedWork W1997969373 @default.
- W2006796360 hasRelatedWork W2006796360 @default.
- W2006796360 hasRelatedWork W2015342157 @default.
- W2006796360 hasRelatedWork W2041745288 @default.
- W2006796360 hasRelatedWork W2063725615 @default.
- W2006796360 hasRelatedWork W2114704594 @default.
- W2006796360 hasRelatedWork W2724632460 @default.
- W2006796360 hasRelatedWork W2803077957 @default.
- W2006796360 hasRelatedWork W2855239543 @default.
- W2006796360 hasRelatedWork W87072672 @default.
- W2006796360 hasVolume "217" @default.
- W2006796360 isParatext "false" @default.
- W2006796360 isRetracted "false" @default.
- W2006796360 magId "2006796360" @default.
- W2006796360 workType "article" @default.