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• W2006798984 abstract "A method to identify genomic elements that promote cap-independent translation is described and is used to identify such elements in the human genome. We report an in vitro selection strategy to identify RNA sequences that mediate cap-independent initiation of translation. This method entails mRNA display of trillions of genomic fragments, selection for initiation of translation and high-throughput deep sequencing. We identified >12,000 translation-enhancing elements (TEEs) in the human genome, generated a high-resolution map of human TEE-bearing regions (TBRs), and validated the function of a subset of sequences in vitro and in cultured cells." @default.
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• W2006798984 date "2013-06-16" @default.
• W2006798984 modified "2023-10-12" @default.
• W2006798984 title "Genome-wide profiling of human cap-independent translation-enhancing elements" @default.
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• W2006798984 doi "https://doi.org/10.1038/nmeth.2522" @default.
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