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- W2006799327 abstract "alpha-2 Adrenergic (A2) receptors and tyrosine hydroxylase (TH) mRNA in the locus coeruleus (LC) were studied using [125I]iodoclonidine and [35S]TH oligonucleotide probe. Spontaneously hypertensive (SHR) rats contained less TH mRNA at their prehypertensive, but not at the well-established hypertensive stage, than age-matched Wistar-Kyoto rats. Furthermore, there is an up-regulation of A2 receptors in SHR rats which is parallel to their blood pressure elevation. The present data suggest that increased A2 receptors in conjunction with TH mRNA reduction in the LC are associated with initiation, but not maintenance of genetic hypertension." @default.
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- W2006799327 date "1991-10-01" @default.
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- W2006799327 title "Quantitative autoradiographic study on tyrosine hydroxylase mRNA with in situ hybridization and α2 adrenergic receptor binding in the locus coeruleus of the spontaneously hypertensive rat" @default.
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- W2006799327 doi "https://doi.org/10.1016/0304-3940(91)90604-r" @default.
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