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- W2006800517 abstract "Several studies have demonstrated that mild hypothermia exhibits a neuroprotective role and it can inhibit endothelial cell apoptosis following ischemia/reperfusion injury by decreasing caspase-3 expression. It is hypothesized that mild hypothermia exhibits neuroprotective effects on neurons exposed to ischemia/reperfusion condition produced by oxygen-glucose deprivation. Mild hypothermia significantly reduced the number of apoptotic neurons, decreased the expression of pro-apoptotic protein Bax and increased mitochondrial membrane potential, with the peak of anti-apoptotic effect appearing between 6 and 12 hours after the injury. These findings indicate that mild hypothermia inhibits neuronal apoptosis following ischemia/reperfusion injury by protecting the mitochondria and that the effective time window is 6–12 hours after ischemia/reperfusion injury." @default.
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- W2006800517 date "2015-01-01" @default.
- W2006800517 modified "2023-10-18" @default.
- W2006800517 title "The pathways by which mild hypothermia inhibits neuronal apoptosis following ischemia/reperfusion injury" @default.
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- W2006800517 doi "https://doi.org/10.4103/1673-5374.150725" @default.
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