FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006802118> ?p ?o ?g. }

• W2006802118 endingPage "439" @default.
• W2006802118 startingPage "431" @default.
• W2006802118 abstract "The cysteinyl-leukotrienes (cysLTs) LTC₄, LTD₄, and LTE₄, are involved in a variety of inflammatory diseases, including asthma, and act on at least two distinct receptors, CysLT₁ and CysLT₂. Specific antagonists of CysLT₁ are currently used to control bronchoconstriction and inflammation in asthmatic patients. The potential role of CysLT₂ in asthma remains poorly understood. A polymorphism in the CysLT₂ gene, resulting in a single amino acid substitution (M201V), was found to be associated with asthma in three separate population studies. Here, we investigated whether the M201V mutation affected the affinity of CysLT₂ for its natural ligands and its signaling efficiency. Human embryonic kidney 293 cells were stably transfected with either wild-type (wt) or mutant (M201V) CysLT₂. Affinity of the M201V receptor for LTC₄ was reduced by 50%, whereas affinity for LTD₄ was essentially lost. LTC₄-induced production of inositol phosphates (IPs) in M201V-expressing cells was significantly decreased at suboptimal concentrations of the ligand, but no difference was observed at high concentrations. In contrast, LTD₄-induced IP production was 10- to 100-fold less in M201V- than in wt-expressing cells. Similar results were also observed with the transactivation of the interleukin-8 promoter induced by LTC₄ or LTD₄. Moreover, in contrast to wt-expressing cells, phosphorylation of nuclear factor κB p65 was absent in LTD₄-stimulated M201V-expressing cells. Likewise, phosphorylation of c-Jun N-terminal kinase was not induced in LTD₄-stimulated M201V cells, whereas activation of extracellular response kinase and p38 was maintained, at least at higher LTD₄ concentrations. Our results indicate that the M201V polymorphism drastically affects CysLT₂ responses to LTD₄ and less to LTC₄." @default.
• W2006802118 created "2016-06-24" @default.
• W2006802118 creator A5035125191 @default.
• W2006802118 creator A5043243939 @default.
• W2006802118 creator A5051739951 @default.
• W2006802118 creator A5061708161 @default.
• W2006802118 date "2010-10-21" @default.
• W2006802118 modified "2023-10-15" @default.
• W2006802118 title "Differential Signaling Defects Associated with the M201V Polymorphism in the Cysteinyl Leukotriene Type 2 Receptor" @default.
• W2006802118 cites W1825353903 @default.
• W2006802118 cites W1908561802 @default.
• W2006802118 cites W1966903065 @default.
• W2006802118 cites W1972923838 @default.
• W2006802118 cites W1977303713 @default.
• W2006802118 cites W1983262394 @default.
• W2006802118 cites W2004351423 @default.
• W2006802118 cites W2012280900 @default.
• W2006802118 cites W2014288352 @default.
• W2006802118 cites W2026086105 @default.
• W2006802118 cites W2028170289 @default.
• W2006802118 cites W2036322615 @default.
• W2006802118 cites W2040452929 @default.
• W2006802118 cites W2042170152 @default.
• W2006802118 cites W2047633306 @default.
• W2006802118 cites W2049443318 @default.
• W2006802118 cites W2049611742 @default.
• W2006802118 cites W2064310141 @default.
• W2006802118 cites W2068156391 @default.
• W2006802118 cites W2071276322 @default.
• W2006802118 cites W2075509773 @default.
• W2006802118 cites W2094589918 @default.
• W2006802118 cites W2096768293 @default.
• W2006802118 cites W2098333708 @default.
• W2006802118 cites W2101668331 @default.
• W2006802118 cites W2103908315 @default.
• W2006802118 cites W2116210034 @default.
• W2006802118 cites W2116594128 @default.
• W2006802118 cites W2118001587 @default.
• W2006802118 cites W2121804671 @default.
• W2006802118 cites W2135689740 @default.
• W2006802118 cites W2146319740 @default.
• W2006802118 cites W2147361992 @default.
• W2006802118 cites W2149122802 @default.
• W2006802118 cites W2149963584 @default.
• W2006802118 cites W2151465226 @default.
• W2006802118 cites W2152288642 @default.
• W2006802118 cites W2161868397 @default.
• W2006802118 cites W2163744692 @default.
• W2006802118 cites W2171451814 @default.
• W2006802118 doi "https://doi.org/10.1124/jpet.110.172411" @default.
• W2006802118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20966037" @default.
• W2006802118 hasPublicationYear "2010" @default.
• W2006802118 type Work @default.
• W2006802118 sameAs 2006802118 @default.
• W2006802118 citedByCount "10" @default.
• W2006802118 countsByYear W20068021182012 @default.
• W2006802118 countsByYear W20068021182014 @default.
• W2006802118 countsByYear W20068021182015 @default.
• W2006802118 countsByYear W20068021182016 @default.
• W2006802118 countsByYear W20068021182021 @default.
• W2006802118 countsByYear W20068021182022 @default.
• W2006802118 crossrefType "journal-article" @default.
• W2006802118 hasAuthorship W2006802118A5035125191 @default.
• W2006802118 hasAuthorship W2006802118A5043243939 @default.
• W2006802118 hasAuthorship W2006802118A5051739951 @default.
• W2006802118 hasAuthorship W2006802118A5061708161 @default.
• W2006802118 hasConcept C104317684 @default.
• W2006802118 hasConcept C126322002 @default.
• W2006802118 hasConcept C1292079 @default.
• W2006802118 hasConcept C143065580 @default.
• W2006802118 hasConcept C150194340 @default.
• W2006802118 hasConcept C153911025 @default.
• W2006802118 hasConcept C170493617 @default.
• W2006802118 hasConcept C185592680 @default.
• W2006802118 hasConcept C207583985 @default.
• W2006802118 hasConcept C2908647359 @default.
• W2006802118 hasConcept C55493867 @default.
• W2006802118 hasConcept C71924100 @default.
• W2006802118 hasConcept C86803240 @default.
• W2006802118 hasConcept C99454951 @default.
• W2006802118 hasConceptScore W2006802118C104317684 @default.
• W2006802118 hasConceptScore W2006802118C126322002 @default.
• W2006802118 hasConceptScore W2006802118C1292079 @default.
• W2006802118 hasConceptScore W2006802118C143065580 @default.
• W2006802118 hasConceptScore W2006802118C150194340 @default.
• W2006802118 hasConceptScore W2006802118C153911025 @default.
• W2006802118 hasConceptScore W2006802118C170493617 @default.
• W2006802118 hasConceptScore W2006802118C185592680 @default.
• W2006802118 hasConceptScore W2006802118C207583985 @default.
• W2006802118 hasConceptScore W2006802118C2908647359 @default.
• W2006802118 hasConceptScore W2006802118C55493867 @default.
• W2006802118 hasConceptScore W2006802118C71924100 @default.
• W2006802118 hasConceptScore W2006802118C86803240 @default.
• W2006802118 hasConceptScore W2006802118C99454951 @default.
• W2006802118 hasIssue "2" @default.
• W2006802118 hasLocation W20068021181 @default.
• W2006802118 hasLocation W20068021182 @default.
• W2006802118 hasOpenAccess W2006802118 @default.

• next