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- W2006816708 abstract "Novel (E)-α-benzylthio chalcones are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (comparable to imatinib, the reference compound) of BCR-ABL phosphorylation in leukemic K562 cells, known to express high levels of BCR-ABL. The ability of such compounds to significantly inhibit K562 cell proliferation suggests that this scaffold could be a promising lead for the development of anticancer agents that are able to block BCR-ABL phosphorylation in leukemic cells." @default.
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- W2006816708 date "2010-03-01" @default.
- W2006816708 modified "2023-10-16" @default.
- W2006816708 title "Design, synthesis and evaluation of (E)-α-benzylthio chalcones as novel inhibitors of BCR-ABL kinase" @default.
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- W2006816708 doi "https://doi.org/10.1016/j.bmc.2010.01.051" @default.
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