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- W2006830260 endingPage "142" @default.
- W2006830260 startingPage "142" @default.
- W2006830260 abstract "The interaction between the receptor activator of NF-κB ligand (RANKL) and its receptor RANK plays a critical role in the development and function of diverse tissues. This review summarizes the studies regarding the functions of RANKL signaling in immune regulatory systems. Previous in vitro and in vivo studies have indicated that the RANKL signal promotes the survival of dendritic cells (DCs), thereby activating the immune response. In addition, RANKL signaling to DCs in the body surface barriers controls self-tolerance and oral-tolerance through regulatory T cell functions. In addition to regulating DC functions, the RANKL and RANK interaction is critical for the development and organization of several lymphoid organs. The RANKL signal initiates the formation of clusters of lymphoid tissue inducer cells, which is crucial for lymph node organogenesis. Moreover, the RANKL-RANK interaction controls the differentiation of M cells, specialized epithelial cells in mucosal tissues, that take up and transcytose antigen particles to control the immune response to pathogens or commensal bacterium. The development of epithelial cells localized in the thymic medulla (mTECs) is also regulated by the RANKL-RANK signal. Given that the unique property of mTECs to express a wide variety of tissue-specific self-antigens is critical for the elimination of self-antigen reactive T cells in the thymus, the RANKL-RANK interaction contributes to the suppression of autoimmunity. Future studies on the roles of the RANKL-RANK system in immune regulatory functions would be informative for the development and application of inhibitors of RANKL signaling for disease treatment." @default.
- W2006830260 created "2016-06-24" @default.
- W2006830260 creator A5015186399 @default.
- W2006830260 creator A5027927884 @default.
- W2006830260 creator A5030163727 @default.
- W2006830260 date "2012-01-01" @default.
- W2006830260 modified "2023-10-16" @default.
- W2006830260 title "RANKL-RANK interaction in immune regulatory systems" @default.
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- W2006830260 doi "https://doi.org/10.5312/wjo.v3.i9.142" @default.