FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006832019> ?p ?o ?g. }

• W2006832019 endingPage "141" @default.
• W2006832019 startingPage "133" @default.
• W2006832019 abstract "The spirochete Borrelia burgdorferi, the etiologic agent of Lyme disease, is transmitted to the host by a feeding Ixodid tick. The spirochete subsequently disseminates through the skin, enters the bloodstream, and becomes systemic. A potential mechanism for this invasiveness was identified with the discovery that B. burgdorferi can bind components of the plasminogen activation system (PAS). The methodology for analyzing the generation of enzymatically active plasmin on the surface of this organism is given, and applied to measure spirochete viability, strain differences, and breakdown of extracellular matrix (ECM) macromolecules. Plasmin acquisition by B. burgdorferi was measured photometrically by a specific chromogenic substrate. The growth of B. burgdorferi in culture was not affected by the presence of active plasmin on the spirochete surface. Plasmin-coated B. burgdorferi degraded the purified (ECM) components fibronectin, laminin, and vitronectin, but not collagen. The addition of B. burgdorferi with surface plasmin to a radiolabeled, native ECM resulted in degradation of noncollagenous protein, as measured by release of solubilized radioactivity. Breakdown of purified ECM components or native ECM did not occur after exposure to untreated spirochetes or spirochetes treated with uPA or PLG alone. These results provide in vitro evidence that enzymatically active plasmin on the surface of B. burgdorferi may be partially responsible for its invasiveness." @default.
• W2006832019 created "2016-06-24" @default.
• W2006832019 creator A5036234089 @default.
• W2006832019 creator A5086392643 @default.
• W2006832019 date "2000-06-01" @default.
• W2006832019 modified "2023-09-27" @default.
• W2006832019 title "The Generation of Enzymatically Active Plasmin on the Surface of Spirochetes" @default.
• W2006832019 cites W1598181676 @default.
• W2006832019 cites W1602370661 @default.
• W2006832019 cites W1926303070 @default.
• W2006832019 cites W1949825747 @default.
• W2006832019 cites W1972146443 @default.
• W2006832019 cites W1973203032 @default.
• W2006832019 cites W1980173932 @default.
• W2006832019 cites W1982646654 @default.
• W2006832019 cites W2000734043 @default.
• W2006832019 cites W2004498133 @default.
• W2006832019 cites W2007245268 @default.
• W2006832019 cites W2010321932 @default.
• W2006832019 cites W2015430118 @default.
• W2006832019 cites W2036895482 @default.
• W2006832019 cites W2043321476 @default.
• W2006832019 cites W2053055972 @default.
• W2006832019 cites W2063367477 @default.
• W2006832019 cites W2074605133 @default.
• W2006832019 cites W2112990955 @default.
• W2006832019 cites W2113950100 @default.
• W2006832019 cites W2117879359 @default.
• W2006832019 cites W2127395738 @default.
• W2006832019 cites W2134259286 @default.
• W2006832019 cites W2135241184 @default.
• W2006832019 cites W2141037678 @default.
• W2006832019 cites W2143679420 @default.
• W2006832019 cites W2145971157 @default.
• W2006832019 cites W2150034821 @default.
• W2006832019 cites W2169075544 @default.
• W2006832019 cites W2234924712 @default.
• W2006832019 cites W23122061 @default.
• W2006832019 cites W254210604 @default.
• W2006832019 cites W2602678057 @default.
• W2006832019 doi "https://doi.org/10.1006/meth.2000.0984" @default.
• W2006832019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10816374" @default.
• W2006832019 hasPublicationYear "2000" @default.
• W2006832019 type Work @default.
• W2006832019 sameAs 2006832019 @default.
• W2006832019 citedByCount "26" @default.
• W2006832019 countsByYear W20068320192012 @default.
• W2006832019 countsByYear W20068320192013 @default.
• W2006832019 countsByYear W20068320192015 @default.
• W2006832019 countsByYear W20068320192018 @default.
• W2006832019 countsByYear W20068320192020 @default.
• W2006832019 crossrefType "journal-article" @default.
• W2006832019 hasAuthorship W2006832019A5036234089 @default.
• W2006832019 hasAuthorship W2006832019A5086392643 @default.
• W2006832019 hasConcept C159654299 @default.
• W2006832019 hasConcept C164144092 @default.
• W2006832019 hasConcept C181199279 @default.
• W2006832019 hasConcept C185592680 @default.
• W2006832019 hasConcept C189165786 @default.
• W2006832019 hasConcept C202751555 @default.
• W2006832019 hasConcept C203014093 @default.
• W2006832019 hasConcept C2779159148 @default.
• W2006832019 hasConcept C2779814568 @default.
• W2006832019 hasConcept C2781071845 @default.
• W2006832019 hasConcept C55493867 @default.
• W2006832019 hasConcept C86492073 @default.
• W2006832019 hasConcept C86803240 @default.
• W2006832019 hasConcept C89423630 @default.
• W2006832019 hasConceptScore W2006832019C159654299 @default.
• W2006832019 hasConceptScore W2006832019C164144092 @default.
• W2006832019 hasConceptScore W2006832019C181199279 @default.
• W2006832019 hasConceptScore W2006832019C185592680 @default.
• W2006832019 hasConceptScore W2006832019C189165786 @default.
• W2006832019 hasConceptScore W2006832019C202751555 @default.
• W2006832019 hasConceptScore W2006832019C203014093 @default.
• W2006832019 hasConceptScore W2006832019C2779159148 @default.
• W2006832019 hasConceptScore W2006832019C2779814568 @default.
• W2006832019 hasConceptScore W2006832019C2781071845 @default.
• W2006832019 hasConceptScore W2006832019C55493867 @default.
• W2006832019 hasConceptScore W2006832019C86492073 @default.
• W2006832019 hasConceptScore W2006832019C86803240 @default.
• W2006832019 hasConceptScore W2006832019C89423630 @default.
• W2006832019 hasIssue "2" @default.
• W2006832019 hasLocation W20068320191 @default.
• W2006832019 hasLocation W20068320192 @default.
• W2006832019 hasOpenAccess W2006832019 @default.
• W2006832019 hasPrimaryLocation W20068320191 @default.
• W2006832019 hasRelatedWork W1216839925 @default.
• W2006832019 hasRelatedWork W1974956317 @default.
• W2006832019 hasRelatedWork W2068202606 @default.
• W2006832019 hasRelatedWork W2170356057 @default.
• W2006832019 hasRelatedWork W2395439073 @default.
• W2006832019 hasRelatedWork W2399974362 @default.
• W2006832019 hasRelatedWork W2401185838 @default.
• W2006832019 hasRelatedWork W2416840308 @default.
• W2006832019 hasRelatedWork W2435662853 @default.
• W2006832019 hasRelatedWork W2171778319 @default.
• W2006832019 hasVolume "21" @default.

• next