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- W2006847300 abstract "The multi-ligand Receptor for Advanced Glycation Endproducts (RAGE) is implicated in the pathogenesis and progression of chronic diseases such as diabetes and immune/inflammatory disorders. Recent studies are uncovering the precise mechanisms by which distinct RAGE ligands bind the extracellular (soluble) domain of the receptor at the V-, C1- and/or C2-immunoglobulin like domains. Experiments using soluble RAGE in animals as a ligand decoy have illustrated largely beneficial effects in reducing vascular and inflammatory stress and, thereby, preventing long-term tissue damage in models of diabetes and immune/inflammatory disorders. Measurement of soluble RAGE levels in the human, both total soluble RAGE and a splice variant-derived product known as endogenous secretory or esRAGE, holds promise for the identification of potential therapeutic targets and/or biomarkers of RAGE activity in disease. In this article, we review the evidence from the rodent to the human implicating RAGE in the diverse disease states in which its ligands accumulate." @default.
- W2006847300 created "2016-06-24" @default.
- W2006847300 creator A5007603996 @default.
- W2006847300 creator A5038128976 @default.
- W2006847300 creator A5051573119 @default.
- W2006847300 date "2010-05-01" @default.
- W2006847300 modified "2023-09-23" @default.
- W2006847300 title "Soluble RAGE: Therapy and biomarker in unraveling the RAGE axis in chronic disease and aging" @default.
- W2006847300 cites W1503258737 @default.
- W2006847300 cites W1513611092 @default.
- W2006847300 cites W1520402836 @default.
- W2006847300 cites W1752045965 @default.
- W2006847300 cites W1825826250 @default.
- W2006847300 cites W1840001967 @default.
- W2006847300 cites W1965497701 @default.
- W2006847300 cites W1970459742 @default.
- W2006847300 cites W1976415918 @default.
- W2006847300 cites W1980101755 @default.
- W2006847300 cites W1987703665 @default.
- W2006847300 cites W1988699763 @default.
- W2006847300 cites W1989591478 @default.
- W2006847300 cites W1990205058 @default.
- W2006847300 cites W1995707828 @default.
- W2006847300 cites W1999684267 @default.
- W2006847300 cites W2005640704 @default.
- W2006847300 cites W2005869447 @default.
- W2006847300 cites W2007281508 @default.
- W2006847300 cites W2008011385 @default.
- W2006847300 cites W2011382030 @default.
- W2006847300 cites W2012772537 @default.
- W2006847300 cites W2017234408 @default.
- W2006847300 cites W2021346724 @default.
- W2006847300 cites W2021882325 @default.
- W2006847300 cites W2022356903 @default.
- W2006847300 cites W2027610820 @default.
- W2006847300 cites W2029777277 @default.
- W2006847300 cites W2038528673 @default.
- W2006847300 cites W2038792388 @default.
- W2006847300 cites W2039780464 @default.
- W2006847300 cites W2043208796 @default.
- W2006847300 cites W2043421454 @default.
- W2006847300 cites W2049167261 @default.
- W2006847300 cites W2052746932 @default.
- W2006847300 cites W2054085768 @default.
- W2006847300 cites W2056248104 @default.
- W2006847300 cites W2061022393 @default.
- W2006847300 cites W2062273929 @default.
- W2006847300 cites W2070943527 @default.
- W2006847300 cites W2071675524 @default.
- W2006847300 cites W2072726731 @default.
- W2006847300 cites W2073714833 @default.
- W2006847300 cites W2075800587 @default.
- W2006847300 cites W2079407096 @default.
- W2006847300 cites W2081080245 @default.
- W2006847300 cites W2091499641 @default.
- W2006847300 cites W2093715230 @default.
- W2006847300 cites W2098098743 @default.
- W2006847300 cites W2099779874 @default.
- W2006847300 cites W2105184398 @default.
- W2006847300 cites W2106697731 @default.
- W2006847300 cites W2106889822 @default.
- W2006847300 cites W2108266187 @default.
- W2006847300 cites W2114688115 @default.
- W2006847300 cites W2115293825 @default.
- W2006847300 cites W2116794323 @default.
- W2006847300 cites W2118385532 @default.
- W2006847300 cites W2120212913 @default.
- W2006847300 cites W2120842870 @default.
- W2006847300 cites W2124136509 @default.
- W2006847300 cites W2127620487 @default.
- W2006847300 cites W2129075447 @default.
- W2006847300 cites W2129902595 @default.
- W2006847300 cites W2130072278 @default.
- W2006847300 cites W2132404990 @default.
- W2006847300 cites W2140491925 @default.
- W2006847300 cites W2141595429 @default.
- W2006847300 cites W2143844746 @default.
- W2006847300 cites W2144663710 @default.
- W2006847300 cites W2145430092 @default.
- W2006847300 cites W2148329662 @default.
- W2006847300 cites W2148715056 @default.
- W2006847300 cites W2149354716 @default.
- W2006847300 cites W2150107415 @default.
- W2006847300 cites W2153914881 @default.
- W2006847300 cites W2162666481 @default.
- W2006847300 cites W2164463504 @default.
- W2006847300 cites W2164714222 @default.
- W2006847300 cites W2167443327 @default.
- W2006847300 cites W2168119720 @default.
- W2006847300 cites W2168191404 @default.
- W2006847300 cites W2409521209 @default.
- W2006847300 cites W2410230004 @default.
- W2006847300 cites W4241103062 @default.
- W2006847300 cites W4245060634 @default.
- W2006847300 doi "https://doi.org/10.1016/j.bcp.2010.01.013" @default.
- W2006847300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2854502" @default.
- W2006847300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20096667" @default.
- W2006847300 hasPublicationYear "2010" @default.