FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006857508> ?p ?o ?g. }

• W2006857508 endingPage "120" @default.
• W2006857508 startingPage "114" @default.
• W2006857508 abstract "Adeno-associated viruses (AAVs) are common infective agents of primates. As such, healthy primates carry a large pool of AAV-specific neutralizing antibodies (NAbs), which inhibit AAV-mediated gene transfer therapeutic strategies. Thus, a clinical method to screen patient candidates for AAV-specific NAbs prior to treatment, especially with the frequently used AAV8 capsid component, will facilitate individualized treatment design and enhance therapeutic efficacy. In this study, we evaluated the efficacy and sensitivity of a passive immunity mouse model to quantitatively assess anti-AAV8 NAb titers, as compared to an in vitro immunoassay. The passive transfer model was established in C57BL/6 mice by tail vein injection of pre-defined sera from 23 male rhesus monkeys. The mice were then administered low dose (3e10 GC/mouse) self-complementary (sc) AAV8. The in vitro NAb assay indicated that 69.57% of the rhesus donors had pre-existing anti-AAV8 NAb. The in vivo NAb assay, however, was better able to detect low NAb titer (≤ 1:5), which can mediate neutralization in vivo. Indeed, 17 rhesus donors (74.0%) had pre-existing anti-AAV8 neutralization by in vivo NAb assay. Our findings indicated that the in vivo NAb assay is superior to the in vitro assay for detecting low NAb titers." @default.
• W2006857508 created "2016-06-24" @default.
• W2006857508 creator A5006117659 @default.
• W2006857508 creator A5009470292 @default.
• W2006857508 creator A5029143479 @default.
• W2006857508 creator A5032757422 @default.
• W2006857508 creator A5066858520 @default.
• W2006857508 creator A5072335707 @default.
• W2006857508 date "2013-01-01" @default.
• W2006857508 modified "2023-10-16" @default.
• W2006857508 title "Assessment of a passive immunity mouse model to quantitatively analyze the impact of neutralizing antibodies on adeno-associated virus-mediated gene transfer" @default.
• W2006857508 cites W1577558588 @default.
• W2006857508 cites W1976329054 @default.
• W2006857508 cites W1988197108 @default.
• W2006857508 cites W1997090549 @default.
• W2006857508 cites W2000185853 @default.
• W2006857508 cites W2009968900 @default.
• W2006857508 cites W2010388612 @default.
• W2006857508 cites W2021337960 @default.
• W2006857508 cites W2023133801 @default.
• W2006857508 cites W2045817726 @default.
• W2006857508 cites W2049592320 @default.
• W2006857508 cites W2052642203 @default.
• W2006857508 cites W2058066097 @default.
• W2006857508 cites W2068074076 @default.
• W2006857508 cites W2076679924 @default.
• W2006857508 cites W2079017842 @default.
• W2006857508 cites W2082025265 @default.
• W2006857508 cites W2086878238 @default.
• W2006857508 cites W2088410491 @default.
• W2006857508 cites W2102539048 @default.
• W2006857508 cites W2111837903 @default.
• W2006857508 cites W2112011162 @default.
• W2006857508 cites W2125160350 @default.
• W2006857508 cites W2128033750 @default.
• W2006857508 cites W2151809142 @default.
• W2006857508 cites W2165926588 @default.
• W2006857508 cites W2170614901 @default.
• W2006857508 doi "https://doi.org/10.1016/j.jim.2012.10.003" @default.
• W2006857508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23063691" @default.
• W2006857508 hasPublicationYear "2013" @default.
• W2006857508 type Work @default.
• W2006857508 sameAs 2006857508 @default.
• W2006857508 citedByCount "9" @default.
• W2006857508 countsByYear W20068575082013 @default.
• W2006857508 countsByYear W20068575082015 @default.
• W2006857508 countsByYear W20068575082017 @default.
• W2006857508 countsByYear W20068575082018 @default.
• W2006857508 countsByYear W20068575082023 @default.
• W2006857508 crossrefType "journal-article" @default.
• W2006857508 hasAuthorship W2006857508A5006117659 @default.
• W2006857508 hasAuthorship W2006857508A5009470292 @default.
• W2006857508 hasAuthorship W2006857508A5029143479 @default.
• W2006857508 hasAuthorship W2006857508A5032757422 @default.
• W2006857508 hasAuthorship W2006857508A5066858520 @default.
• W2006857508 hasAuthorship W2006857508A5072335707 @default.
• W2006857508 hasConcept C104317684 @default.
• W2006857508 hasConcept C111599444 @default.
• W2006857508 hasConcept C14086860 @default.
• W2006857508 hasConcept C150903083 @default.
• W2006857508 hasConcept C153911025 @default.
• W2006857508 hasConcept C159047783 @default.
• W2006857508 hasConcept C159654299 @default.
• W2006857508 hasConcept C202751555 @default.
• W2006857508 hasConcept C202878990 @default.
• W2006857508 hasConcept C203014093 @default.
• W2006857508 hasConcept C207001950 @default.
• W2006857508 hasConcept C2522874641 @default.
• W2006857508 hasConcept C2776548049 @default.
• W2006857508 hasConcept C2778107364 @default.
• W2006857508 hasConcept C2779261636 @default.
• W2006857508 hasConcept C2779341262 @default.
• W2006857508 hasConcept C32611913 @default.
• W2006857508 hasConcept C40767141 @default.
• W2006857508 hasConcept C55493867 @default.
• W2006857508 hasConcept C86803240 @default.
• W2006857508 hasConcept C8891405 @default.
• W2006857508 hasConcept C92087593 @default.
• W2006857508 hasConceptScore W2006857508C104317684 @default.
• W2006857508 hasConceptScore W2006857508C111599444 @default.
• W2006857508 hasConceptScore W2006857508C14086860 @default.
• W2006857508 hasConceptScore W2006857508C150903083 @default.
• W2006857508 hasConceptScore W2006857508C153911025 @default.
• W2006857508 hasConceptScore W2006857508C159047783 @default.
• W2006857508 hasConceptScore W2006857508C159654299 @default.
• W2006857508 hasConceptScore W2006857508C202751555 @default.
• W2006857508 hasConceptScore W2006857508C202878990 @default.
• W2006857508 hasConceptScore W2006857508C203014093 @default.
• W2006857508 hasConceptScore W2006857508C207001950 @default.
• W2006857508 hasConceptScore W2006857508C2522874641 @default.
• W2006857508 hasConceptScore W2006857508C2776548049 @default.
• W2006857508 hasConceptScore W2006857508C2778107364 @default.
• W2006857508 hasConceptScore W2006857508C2779261636 @default.
• W2006857508 hasConceptScore W2006857508C2779341262 @default.
• W2006857508 hasConceptScore W2006857508C32611913 @default.
• W2006857508 hasConceptScore W2006857508C40767141 @default.
• W2006857508 hasConceptScore W2006857508C55493867 @default.
• W2006857508 hasConceptScore W2006857508C86803240 @default.

• next