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- W2006860240 abstract "The discovery of the calcium-sensing receptor (CaR), a G protein-coupled receptor, has led to the elucidation of the pivotal roles of the CaR in systemic calcium homeostasis. The receptor is situated on the chief cells of the parathyroid glands, where it senses the extracellular Ca2+ concentration and in turn alters the rate of secretion of parathyroid hormone (PTH). The intracellular signal pathways to which the CaR couples include, but are not limited to, phospholipase C (PLC), and mitogen-activated protein kinases. The receptor is widely expressed in various tissues and likely serves important cellular functions beyond that of maintaining systemic calcium homeostasis. Functionally important mutations in the receptor have been found to cause disorders in calcium homeostasis due both to changes in the set point for PTH secretion and to the control of renal calcium excretion. These mutations cause hypercalcemia when the mutation inactivates the receptor and cause hypocalcemia when the mutation activates the receptor. Recent studies have revealed the presence of circulating autoantibodies to the calcium-sensing receptor in humans, with the clinical presentation the same as that for diseases caused by mutations in the CaR. In renal secondary hyperparathyroidism, a drug that stimulates the receptor (calcimimetic) shows great promise as a medical treatment for this condition." @default.
- W2006860240 created "2016-06-24" @default.
- W2006860240 creator A5036594335 @default.
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- W2006860240 date "2003-01-01" @default.
- W2006860240 modified "2023-10-13" @default.
- W2006860240 title "The calcium-sensing receptor in human disease" @default.
- W2006860240 cites W118706930 @default.
- W2006860240 cites W1586082476 @default.
- W2006860240 cites W1908978414 @default.
- W2006860240 cites W1964592585 @default.
- W2006860240 cites W1967777479 @default.
- W2006860240 cites W1969619665 @default.
- W2006860240 cites W1972065681 @default.
- W2006860240 cites W1972864808 @default.
- W2006860240 cites W1972905925 @default.
- W2006860240 cites W1973882361 @default.
- W2006860240 cites W1973988692 @default.
- W2006860240 cites W1975297178 @default.
- W2006860240 cites W1975603887 @default.
- W2006860240 cites W1975747275 @default.
- W2006860240 cites W1977451393 @default.
- W2006860240 cites W1977864809 @default.
- W2006860240 cites W1979249979 @default.
- W2006860240 cites W1986261291 @default.
- W2006860240 cites W1986702099 @default.
- W2006860240 cites W1994494042 @default.
- W2006860240 cites W1994723791 @default.
- W2006860240 cites W1995638940 @default.
- W2006860240 cites W1998843632 @default.
- W2006860240 cites W2002372547 @default.
- W2006860240 cites W2003197654 @default.
- W2006860240 cites W2009441758 @default.
- W2006860240 cites W2010272680 @default.
- W2006860240 cites W2010599278 @default.
- W2006860240 cites W2022667485 @default.
- W2006860240 cites W2029291782 @default.
- W2006860240 cites W2031455439 @default.
- W2006860240 cites W2035995595 @default.
- W2006860240 cites W2044700868 @default.
- W2006860240 cites W2046829977 @default.
- W2006860240 cites W2047344940 @default.
- W2006860240 cites W2048117338 @default.
- W2006860240 cites W2050509937 @default.
- W2006860240 cites W2051708905 @default.
- W2006860240 cites W2054828183 @default.
- W2006860240 cites W2066958101 @default.
- W2006860240 cites W2067466593 @default.
- W2006860240 cites W2069354376 @default.
- W2006860240 cites W2077516065 @default.
- W2006860240 cites W2079475485 @default.
- W2006860240 cites W2079537980 @default.
- W2006860240 cites W2081028949 @default.
- W2006860240 cites W2089414941 @default.
- W2006860240 cites W2091303924 @default.
- W2006860240 cites W2102455745 @default.
- W2006860240 cites W2103871176 @default.
- W2006860240 cites W2105198696 @default.
- W2006860240 cites W2106590998 @default.
- W2006860240 cites W2106856165 @default.
- W2006860240 cites W2108298089 @default.
- W2006860240 cites W2109484905 @default.
- W2006860240 cites W2117219576 @default.
- W2006860240 cites W2117403606 @default.
- W2006860240 cites W2125845212 @default.
- W2006860240 cites W2128686820 @default.
- W2006860240 cites W2138733161 @default.
- W2006860240 cites W2143878967 @default.
- W2006860240 cites W2145930493 @default.
- W2006860240 cites W2150335133 @default.
- W2006860240 cites W2150910286 @default.
- W2006860240 cites W2153170303 @default.
- W2006860240 cites W2157138210 @default.
- W2006860240 cites W2162462842 @default.
- W2006860240 cites W2162819494 @default.
- W2006860240 cites W2169649776 @default.
- W2006860240 cites W2170949021 @default.
- W2006860240 cites W2183475472 @default.
- W2006860240 cites W2220745604 @default.
- W2006860240 cites W2326971455 @default.
- W2006860240 cites W2335952874 @default.
- W2006860240 cites W2409364584 @default.
- W2006860240 cites W2414625796 @default.
- W2006860240 cites W2472794554 @default.
- W2006860240 cites W1966674735 @default.
- W2006860240 doi "https://doi.org/10.2741/1068" @default.
- W2006860240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12700051" @default.
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