FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006864410> ?p ?o ?g. }

• W2006864410 endingPage "852" @default.
• W2006864410 startingPage "846" @default.
• W2006864410 abstract "The course of a malignant islet cell tumor, producing increased levels of both insulin and glucagon, was studied clinically and in vitro for two years. The patient presented with hypoglycemia, and extensive hepatic metastases were present. Instead of biopsy alone, it was elected to remove the primary in the tail of the pancreas, and subtotal pancreatectomy was performed. There followed a six month interval without hypoglycemia, during which immunoreactive insulin (IRI) decreased (though remaining elevated) and immunoreactive glucagon (IRG) increased markedly. The tumor and a liver metastasis contained elevated IRI and IRG with immunofluorescence for insulin, though typical beta and alpha cells were not present on electron microscopy. A preparation of a monolayer culture of a liver metastasis decreased its IRI production with a similar time course to the clinical improvement, though rapid cell growth continued. Streptozotocin in vitro was markedly cytotoxic. In vivo Streptozotocin caused tumor regression, increase in fasting plasma glucose, decrease in plasma IRI and IRG, and improvement of glucose tolerance. Thus, this case showed elevated IRG in plasma and tumor, improvement in glucoregulation upon excision of the primary, and both in vitro cytotoxicity and clinical improvement with Streptozotocin. It is suggested (1) that cases refractory to therapy directed toward suppression of insulin secretion might benefit from removal of the primary and (2) that further use of cultures of such tumors should be initiated to establish whether they might be useful for predicting in vivo effectiveness of cytotoxic agents." @default.
• W2006864410 created "2016-06-24" @default.
• W2006864410 creator A5003574303 @default.
• W2006864410 creator A5010847843 @default.
• W2006864410 creator A5035718630 @default.
• W2006864410 creator A5052790867 @default.
• W2006864410 creator A5074307097 @default.
• W2006864410 creator A5087149160 @default.
• W2006864410 date "1978-06-01" @default.
• W2006864410 modified "2023-09-27" @default.
• W2006864410 title "Remission of hypoglycemia after partial resection of a metastatic islet cell tumor" @default.
• W2006864410 cites W1496761621 @default.
• W2006864410 cites W1514491077 @default.
• W2006864410 cites W1589619983 @default.
• W2006864410 cites W1980292660 @default.
• W2006864410 cites W1981696346 @default.
• W2006864410 cites W1987679857 @default.
• W2006864410 cites W1992784338 @default.
• W2006864410 cites W1997806672 @default.
• W2006864410 cites W2000967402 @default.
• W2006864410 cites W2002493921 @default.
• W2006864410 cites W2008718591 @default.
• W2006864410 cites W2010375996 @default.
• W2006864410 cites W2011075990 @default.
• W2006864410 cites W2022447306 @default.
• W2006864410 cites W2026944813 @default.
• W2006864410 cites W2044597108 @default.
• W2006864410 cites W2046028546 @default.
• W2006864410 cites W2047472037 @default.
• W2006864410 cites W2062532102 @default.
• W2006864410 cites W2066959642 @default.
• W2006864410 cites W2078300221 @default.
• W2006864410 cites W2123568197 @default.
• W2006864410 cites W2130697978 @default.
• W2006864410 cites W2142748811 @default.
• W2006864410 cites W2339959198 @default.
• W2006864410 doi "https://doi.org/10.1016/0002-9610(78)90179-4" @default.
• W2006864410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/208422" @default.
• W2006864410 hasPublicationYear "1978" @default.
• W2006864410 type Work @default.
• W2006864410 sameAs 2006864410 @default.
• W2006864410 citedByCount "4" @default.
• W2006864410 crossrefType "journal-article" @default.
• W2006864410 hasAuthorship W2006864410A5003574303 @default.
• W2006864410 hasAuthorship W2006864410A5010847843 @default.
• W2006864410 hasAuthorship W2006864410A5035718630 @default.
• W2006864410 hasAuthorship W2006864410A5052790867 @default.
• W2006864410 hasAuthorship W2006864410A5074307097 @default.
• W2006864410 hasAuthorship W2006864410A5087149160 @default.
• W2006864410 hasConcept C121608353 @default.
• W2006864410 hasConcept C126322002 @default.
• W2006864410 hasConcept C134018914 @default.
• W2006864410 hasConcept C150903083 @default.
• W2006864410 hasConcept C165220095 @default.
• W2006864410 hasConcept C207001950 @default.
• W2006864410 hasConcept C2775934546 @default.
• W2006864410 hasConcept C2778563252 @default.
• W2006864410 hasConcept C2778764654 @default.
• W2006864410 hasConcept C2779013556 @default.
• W2006864410 hasConcept C2779280383 @default.
• W2006864410 hasConcept C2779306644 @default.
• W2006864410 hasConcept C2780668416 @default.
• W2006864410 hasConcept C555293320 @default.
• W2006864410 hasConcept C71924100 @default.
• W2006864410 hasConcept C86803240 @default.
• W2006864410 hasConceptScore W2006864410C121608353 @default.
• W2006864410 hasConceptScore W2006864410C126322002 @default.
• W2006864410 hasConceptScore W2006864410C134018914 @default.
• W2006864410 hasConceptScore W2006864410C150903083 @default.
• W2006864410 hasConceptScore W2006864410C165220095 @default.
• W2006864410 hasConceptScore W2006864410C207001950 @default.
• W2006864410 hasConceptScore W2006864410C2775934546 @default.
• W2006864410 hasConceptScore W2006864410C2778563252 @default.
• W2006864410 hasConceptScore W2006864410C2778764654 @default.
• W2006864410 hasConceptScore W2006864410C2779013556 @default.
• W2006864410 hasConceptScore W2006864410C2779280383 @default.
• W2006864410 hasConceptScore W2006864410C2779306644 @default.
• W2006864410 hasConceptScore W2006864410C2780668416 @default.
• W2006864410 hasConceptScore W2006864410C555293320 @default.
• W2006864410 hasConceptScore W2006864410C71924100 @default.
• W2006864410 hasConceptScore W2006864410C86803240 @default.
• W2006864410 hasIssue "6" @default.
• W2006864410 hasLocation W20068644101 @default.
• W2006864410 hasLocation W20068644102 @default.
• W2006864410 hasOpenAccess W2006864410 @default.
• W2006864410 hasPrimaryLocation W20068644101 @default.
• W2006864410 hasRelatedWork W125622540 @default.
• W2006864410 hasRelatedWork W1972212762 @default.
• W2006864410 hasRelatedWork W1996874443 @default.
• W2006864410 hasRelatedWork W2017797235 @default.
• W2006864410 hasRelatedWork W2028699422 @default.
• W2006864410 hasRelatedWork W2057434408 @default.
• W2006864410 hasRelatedWork W2058969843 @default.
• W2006864410 hasRelatedWork W2068655959 @default.
• W2006864410 hasRelatedWork W2084878141 @default.
• W2006864410 hasRelatedWork W2097857221 @default.
• W2006864410 hasVolume "135" @default.
• W2006864410 isParatext "false" @default.

• next