FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006875006> ?p ?o ?g. }

• W2006875006 endingPage "13410" @default.
• W2006875006 startingPage "13399" @default.
• W2006875006 abstract "Anatomically incomplete spinal cord injuries are often followed by considerable functional recovery in patients and animal models, largely because of processes of neuronal plasticity. In contrast to the corticospinal system, where sprouting of fibers and rearrangements of circuits in response to lesions have been well studied, structural adaptations within descending brainstem pathways and intraspinal networks are poorly investigated, despite the recognized physiological significance of these systems across species. In the present study, spontaneous neuroanatomical plasticity of severed bulbospinal systems and propriospinal neurons was investigated following unilateral C4 spinal hemisection in adult rats. Injection of retrograde tracer into the ipsilesional segments C3-C4 revealed a specific increase in the projection from the ipsilesional gigantocellular reticular nucleus in response to the injury. Substantial regenerative fiber sprouting of reticulospinal axons above the injury site was demonstrated by anterograde tracing. Regrowing reticulospinal fibers exhibited excitatory, vGLUT2-positive varicosities, indicating their synaptic integration into spinal networks. Reticulospinal fibers formed close appositions onto descending, double-midline crossing C3-C4 propriospinal neurons, which crossed the lesion site in the intact half of the spinal cord and recrossed to the denervated cervical hemicord below the injury. These propriospinal projections around the lesion were significantly enhanced after injury. Our results suggest that severed reticulospinal fibers, which are part of the phylogenetically oldest motor command system, spontaneously arborize and form contacts onto a plastic propriospinal relay, thereby bypassing the lesion. These rearrangements were accompanied by substantial locomotor recovery, implying a potential physiological relevance of the detour in restoration of motor function after spinal injury." @default.
• W2006875006 created "2016-06-24" @default.
• W2006875006 creator A5005216590 @default.
• W2006875006 creator A5028871525 @default.
• W2006875006 creator A5033387872 @default.
• W2006875006 creator A5057817479 @default.
• W2006875006 creator A5068706250 @default.
• W2006875006 creator A5073371921 @default.
• W2006875006 creator A5079308334 @default.
• W2006875006 creator A5084476543 @default.
• W2006875006 creator A5090343638 @default.
• W2006875006 date "2014-10-01" @default.
• W2006875006 modified "2023-10-17" @default.
• W2006875006 title "Bridging the Gap: A Reticulo-Propriospinal Detour Bypassing an Incomplete Spinal Cord Injury" @default.
• W2006875006 cites W1521385720 @default.
• W2006875006 cites W1557272041 @default.
• W2006875006 cites W1963586813 @default.
• W2006875006 cites W1969428442 @default.
• W2006875006 cites W1972576157 @default.
• W2006875006 cites W1973726191 @default.
• W2006875006 cites W1974432822 @default.
• W2006875006 cites W1974458882 @default.
• W2006875006 cites W1974669167 @default.
• W2006875006 cites W1979561559 @default.
• W2006875006 cites W1979947358 @default.
• W2006875006 cites W1980859391 @default.
• W2006875006 cites W1982136112 @default.
• W2006875006 cites W1982750178 @default.
• W2006875006 cites W1987160249 @default.
• W2006875006 cites W1994538792 @default.
• W2006875006 cites W1995072725 @default.
• W2006875006 cites W1996327998 @default.
• W2006875006 cites W1998241928 @default.
• W2006875006 cites W2009857359 @default.
• W2006875006 cites W2010058748 @default.
• W2006875006 cites W2010460856 @default.
• W2006875006 cites W2022705283 @default.
• W2006875006 cites W2024307232 @default.
• W2006875006 cites W2030984604 @default.
• W2006875006 cites W2031893399 @default.
• W2006875006 cites W2032972266 @default.
• W2006875006 cites W2034365239 @default.
• W2006875006 cites W2037170304 @default.
• W2006875006 cites W2038894443 @default.
• W2006875006 cites W2052129348 @default.
• W2006875006 cites W2068467384 @default.
• W2006875006 cites W2074391567 @default.
• W2006875006 cites W2074630923 @default.
• W2006875006 cites W2076492394 @default.
• W2006875006 cites W2084308636 @default.
• W2006875006 cites W2092507916 @default.
• W2006875006 cites W2096816417 @default.
• W2006875006 cites W2099600411 @default.
• W2006875006 cites W2100728233 @default.
• W2006875006 cites W2111498472 @default.
• W2006875006 cites W2117502762 @default.
• W2006875006 cites W2132301122 @default.
• W2006875006 cites W2136681631 @default.
• W2006875006 cites W2140414778 @default.
• W2006875006 cites W2152940329 @default.
• W2006875006 cites W2173189813 @default.
• W2006875006 cites W2605308702 @default.
• W2006875006 doi "https://doi.org/10.1523/jneurosci.0701-14.2014" @default.
• W2006875006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6608315" @default.
• W2006875006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25274818" @default.
• W2006875006 hasPublicationYear "2014" @default.
• W2006875006 type Work @default.
• W2006875006 sameAs 2006875006 @default.
• W2006875006 citedByCount "117" @default.
• W2006875006 countsByYear W20068750062015 @default.
• W2006875006 countsByYear W20068750062016 @default.
• W2006875006 countsByYear W20068750062017 @default.
• W2006875006 countsByYear W20068750062018 @default.
• W2006875006 countsByYear W20068750062019 @default.
• W2006875006 countsByYear W20068750062020 @default.
• W2006875006 countsByYear W20068750062021 @default.
• W2006875006 countsByYear W20068750062022 @default.
• W2006875006 countsByYear W20068750062023 @default.
• W2006875006 crossrefType "journal-article" @default.
• W2006875006 hasAuthorship W2006875006A5005216590 @default.
• W2006875006 hasAuthorship W2006875006A5028871525 @default.
• W2006875006 hasAuthorship W2006875006A5033387872 @default.
• W2006875006 hasAuthorship W2006875006A5057817479 @default.
• W2006875006 hasAuthorship W2006875006A5068706250 @default.
• W2006875006 hasAuthorship W2006875006A5073371921 @default.
• W2006875006 hasAuthorship W2006875006A5079308334 @default.
• W2006875006 hasAuthorship W2006875006A5084476543 @default.
• W2006875006 hasAuthorship W2006875006A5090343638 @default.
• W2006875006 hasBestOaLocation W20068750061 @default.
• W2006875006 hasConcept C105702510 @default.
• W2006875006 hasConcept C142724271 @default.
• W2006875006 hasConcept C169760540 @default.
• W2006875006 hasConcept C2778334475 @default.
• W2006875006 hasConcept C2778655484 @default.
• W2006875006 hasConcept C2779089633 @default.
• W2006875006 hasConcept C2780775167 @default.
• W2006875006 hasConcept C2781156865 @default.
• W2006875006 hasConcept C529278444 @default.

• next