Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006876318> ?p ?o ?g. }
- W2006876318 endingPage "S944" @default.
- W2006876318 startingPage "S929" @default.
- W2006876318 abstract "High pressure has emerged as an important tool to tackle several problems in medicine and biotechnology. Misfolded proteins, aggregates and amyloids have been studied, which point toward the understanding of the protein misfolding diseases. High hydrostatic pressure (HHP) has also been used to dissociate non-amyloid aggregates and inclusion bodies. The diverse range of diseases that result from protein misfolding has made this theme an important research focus for pharmaceutical and biotech companies. The use of high pressure promises to contribute to identifying the mechanisms behind these defects and creating therapies against these diseases. High pressure has also been used to study viruses and other infectious agents for the purpose of sterilization and in the development of vaccines. Using pressure, we have detected the presence of a ribonucleoprotein intermediate, where the coat protein is partially unfolded but bound to RNA. These intermediates are potential targets for antiviral compounds. The ability of pressure to inactivate viruses, prions and bacteria has been evaluated with a view toward the applications of vaccine development and virus sterilization. Recent studies demonstrate that pressure causes virus inactivation while preserving the immunogenic properties. There is increasing evidence that a high-pressure cycle traps a virus in the 'fusion intermediate state', not infectious but highly immunogenic." @default.
- W2006876318 created "2016-06-24" @default.
- W2006876318 creator A5016000542 @default.
- W2006876318 creator A5037403938 @default.
- W2006876318 creator A5052063647 @default.
- W2006876318 creator A5054367986 @default.
- W2006876318 creator A5068374981 @default.
- W2006876318 date "2004-03-26" @default.
- W2006876318 modified "2023-10-17" @default.
- W2006876318 title "High-pressure applications in medicine and pharmacology" @default.
- W2006876318 cites W1505778706 @default.
- W2006876318 cites W1519426644 @default.
- W2006876318 cites W1527671059 @default.
- W2006876318 cites W1550390391 @default.
- W2006876318 cites W1551315742 @default.
- W2006876318 cites W1598287767 @default.
- W2006876318 cites W1914707047 @default.
- W2006876318 cites W1963955763 @default.
- W2006876318 cites W1967802967 @default.
- W2006876318 cites W1968324562 @default.
- W2006876318 cites W1969880312 @default.
- W2006876318 cites W1971071753 @default.
- W2006876318 cites W1973952007 @default.
- W2006876318 cites W1974137193 @default.
- W2006876318 cites W1979083852 @default.
- W2006876318 cites W1980125299 @default.
- W2006876318 cites W1984979938 @default.
- W2006876318 cites W1991723190 @default.
- W2006876318 cites W1993637257 @default.
- W2006876318 cites W1994437514 @default.
- W2006876318 cites W1995253199 @default.
- W2006876318 cites W1995415074 @default.
- W2006876318 cites W2000645263 @default.
- W2006876318 cites W2001461112 @default.
- W2006876318 cites W2004630111 @default.
- W2006876318 cites W2005694227 @default.
- W2006876318 cites W2010622646 @default.
- W2006876318 cites W2012563600 @default.
- W2006876318 cites W2016389662 @default.
- W2006876318 cites W2016989643 @default.
- W2006876318 cites W2019422314 @default.
- W2006876318 cites W2027616961 @default.
- W2006876318 cites W2028719271 @default.
- W2006876318 cites W2033640026 @default.
- W2006876318 cites W2033950336 @default.
- W2006876318 cites W2037313630 @default.
- W2006876318 cites W2037663557 @default.
- W2006876318 cites W2037842899 @default.
- W2006876318 cites W2038721018 @default.
- W2006876318 cites W2044788929 @default.
- W2006876318 cites W2047046753 @default.
- W2006876318 cites W2047392517 @default.
- W2006876318 cites W2047596219 @default.
- W2006876318 cites W2051034236 @default.
- W2006876318 cites W2058769115 @default.
- W2006876318 cites W2061241298 @default.
- W2006876318 cites W2063249119 @default.
- W2006876318 cites W2064009192 @default.
- W2006876318 cites W2068586079 @default.
- W2006876318 cites W2070504654 @default.
- W2006876318 cites W2073001839 @default.
- W2006876318 cites W2076676971 @default.
- W2006876318 cites W2076834744 @default.
- W2006876318 cites W2077000240 @default.
- W2006876318 cites W2080322645 @default.
- W2006876318 cites W2080686452 @default.
- W2006876318 cites W2081099082 @default.
- W2006876318 cites W2083655185 @default.
- W2006876318 cites W2088533660 @default.
- W2006876318 cites W2091808670 @default.
- W2006876318 cites W2097965815 @default.
- W2006876318 cites W2102335249 @default.
- W2006876318 cites W2105872266 @default.
- W2006876318 cites W2107969787 @default.
- W2006876318 cites W2115074076 @default.
- W2006876318 cites W2120288795 @default.
- W2006876318 cites W2123536401 @default.
- W2006876318 cites W2123701613 @default.
- W2006876318 cites W2132228958 @default.
- W2006876318 cites W2133641667 @default.
- W2006876318 cites W2138803959 @default.
- W2006876318 cites W2141250779 @default.
- W2006876318 cites W2150708096 @default.
- W2006876318 cites W2152832434 @default.
- W2006876318 cites W2154589026 @default.
- W2006876318 cites W2157914516 @default.
- W2006876318 cites W2158675454 @default.
- W2006876318 cites W2162875257 @default.
- W2006876318 cites W4247577236 @default.
- W2006876318 doi "https://doi.org/10.1088/0953-8984/16/14/002" @default.
- W2006876318 hasPublicationYear "2004" @default.
- W2006876318 type Work @default.
- W2006876318 sameAs 2006876318 @default.
- W2006876318 citedByCount "17" @default.
- W2006876318 countsByYear W20068763182012 @default.
- W2006876318 countsByYear W20068763182013 @default.
- W2006876318 countsByYear W20068763182014 @default.
- W2006876318 countsByYear W20068763182015 @default.