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• W2006892341 endingPage "1667" @default.
• W2006892341 startingPage "1659" @default.
• W2006892341 abstract "The human pathogen Vibrio cholerae carries a chromosomal superintegron (SI). The SI contains an array of hundreds of gene cassettes organized in tandem which are stable under conditions when no particular stress is applied to bacteria (such as during laboratory growth). Rearrangements of these cassettes are catalyzed by the activity of the associated integron integrase. Understanding the regulation of integrase expression is pivotal to fully comprehending the role played by this genetic reservoir for bacterial adaptation and its connection with the development of antibiotic resistance. Our previous work established that the integrase is regulated by the bacterial SOS response and that it is induced during bacterial conjugation. Here, we show that transformation, another horizontal gene transfer (HGT) mechanism, also triggers integrase expression through SOS induction, underlining the importance of HGT in genome plasticity. Moreover, we report a new cyclic AMP (cAMP)-cAMP receptor protein (CRP)-dependent regulation mechanism of the integrase, highlighting the influence of the extracellular environment on chromosomal gene content. Altogether, our data suggest an interplay between different stress responses and regulatory pathways for the modulation of the recombinase expression, thus showing how the SI remodeling mechanism is merged into bacterial physiology." @default.
• W2006892341 created "2016-06-24" @default.
• W2006892341 creator A5020926846 @default.
• W2006892341 creator A5033278912 @default.
• W2006892341 creator A5072020647 @default.
• W2006892341 date "2012-04-01" @default.
• W2006892341 modified "2023-09-30" @default.
• W2006892341 title "Connecting Environment and Genome Plasticity in the Characterization of Transformation-Induced SOS Regulation and Carbon Catabolite Control of the Vibrio cholerae Integron Integrase" @default.
• W2006892341 cites W100769722 @default.
• W2006892341 cites W1513442717 @default.
• W2006892341 cites W1615461297 @default.
• W2006892341 cites W1886048099 @default.
• W2006892341 cites W1927570869 @default.
• W2006892341 cites W1967190780 @default.
• W2006892341 cites W1968055594 @default.
• W2006892341 cites W1970056626 @default.
• W2006892341 cites W1974127479 @default.
• W2006892341 cites W1975182786 @default.
• W2006892341 cites W1977516923 @default.
• W2006892341 cites W1982011873 @default.
• W2006892341 cites W1992595091 @default.
• W2006892341 cites W1994782227 @default.
• W2006892341 cites W1996703311 @default.
• W2006892341 cites W1997337736 @default.
• W2006892341 cites W1997873483 @default.
• W2006892341 cites W2000106451 @default.
• W2006892341 cites W2001815504 @default.
• W2006892341 cites W2005601631 @default.
• W2006892341 cites W2008088946 @default.
• W2006892341 cites W2008821578 @default.
• W2006892341 cites W2009690857 @default.
• W2006892341 cites W2009874878 @default.
• W2006892341 cites W2013505287 @default.
• W2006892341 cites W2014982379 @default.
• W2006892341 cites W2020296469 @default.
• W2006892341 cites W2022515934 @default.
• W2006892341 cites W2024436097 @default.
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• W2006892341 cites W2038683612 @default.
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• W2006892341 cites W2047606370 @default.
• W2006892341 cites W2050499128 @default.
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• W2006892341 cites W2056034210 @default.
• W2006892341 cites W2058729834 @default.
• W2006892341 cites W2059206113 @default.
• W2006892341 cites W2061010304 @default.
• W2006892341 cites W2063106548 @default.
• W2006892341 cites W2065310225 @default.
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• W2006892341 cites W2138097369 @default.
• W2006892341 cites W2149681189 @default.
• W2006892341 cites W2150553635 @default.
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• W2006892341 doi "https://doi.org/10.1128/jb.05982-11" @default.
• W2006892341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3302476" @default.
• W2006892341 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22287520" @default.
• W2006892341 hasPublicationYear "2012" @default.
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