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• W2006902212 abstract "RationaleTo investigate changes and significance of CD4+CD25+ Foxp3+ regulatory T cells (Treg) in peripheral blood of silica exposed rats at different disease stages and explore the role that Treg play in the development of silicosis.MethodsForty healthy male SD rats were randomly divided, into an experimental group of 24 rats and a control group of 16 rats. One ml silica suspension (40 mg) or an equal amount of saline was administrated via intratracheal instillation. Animals were sacrificed on the 7th, 14th, 21st and 28th day after instillation. The levels of Treg were detected by flow cytometry.ResultsDuring the acute alveolitis (on the 7th day), the level of Treg was 2.6760.73% in silicotic rats and 4.0260.64% in control rats(P<0.05); during the development of granuloma (on the 14th day), the levels of Treg in silicotic rats increased slightly (3.84 6 0.84%) and approached those of the control group (4.11 6 0.76%); on the 21st day, Treg in the experimental group (4.12 6 0.78%) was higher than in the control group (4.07 6 0.69%), but there was no stastic difference; during the stage of high granuloma and fibrosis (on the 28th day), Treg were significantly increased in the experimental group compared to the control group (5.37 6 0.89% vs 4.16 6 0.72%, P<0.05).ConclusionsTreg numbers are reduced and subsequently increased following silica exposure and may play a role in the maintenance of immune tolerance and the development of silicosis. RationaleTo investigate changes and significance of CD4+CD25+ Foxp3+ regulatory T cells (Treg) in peripheral blood of silica exposed rats at different disease stages and explore the role that Treg play in the development of silicosis. To investigate changes and significance of CD4+CD25+ Foxp3+ regulatory T cells (Treg) in peripheral blood of silica exposed rats at different disease stages and explore the role that Treg play in the development of silicosis. MethodsForty healthy male SD rats were randomly divided, into an experimental group of 24 rats and a control group of 16 rats. One ml silica suspension (40 mg) or an equal amount of saline was administrated via intratracheal instillation. Animals were sacrificed on the 7th, 14th, 21st and 28th day after instillation. The levels of Treg were detected by flow cytometry. Forty healthy male SD rats were randomly divided, into an experimental group of 24 rats and a control group of 16 rats. One ml silica suspension (40 mg) or an equal amount of saline was administrated via intratracheal instillation. Animals were sacrificed on the 7th, 14th, 21st and 28th day after instillation. The levels of Treg were detected by flow cytometry. ResultsDuring the acute alveolitis (on the 7th day), the level of Treg was 2.6760.73% in silicotic rats and 4.0260.64% in control rats(P<0.05); during the development of granuloma (on the 14th day), the levels of Treg in silicotic rats increased slightly (3.84 6 0.84%) and approached those of the control group (4.11 6 0.76%); on the 21st day, Treg in the experimental group (4.12 6 0.78%) was higher than in the control group (4.07 6 0.69%), but there was no stastic difference; during the stage of high granuloma and fibrosis (on the 28th day), Treg were significantly increased in the experimental group compared to the control group (5.37 6 0.89% vs 4.16 6 0.72%, P<0.05). During the acute alveolitis (on the 7th day), the level of Treg was 2.6760.73% in silicotic rats and 4.0260.64% in control rats(P<0.05); during the development of granuloma (on the 14th day), the levels of Treg in silicotic rats increased slightly (3.84 6 0.84%) and approached those of the control group (4.11 6 0.76%); on the 21st day, Treg in the experimental group (4.12 6 0.78%) was higher than in the control group (4.07 6 0.69%), but there was no stastic difference; during the stage of high granuloma and fibrosis (on the 28th day), Treg were significantly increased in the experimental group compared to the control group (5.37 6 0.89% vs 4.16 6 0.72%, P<0.05). ConclusionsTreg numbers are reduced and subsequently increased following silica exposure and may play a role in the maintenance of immune tolerance and the development of silicosis. Treg numbers are reduced and subsequently increased following silica exposure and may play a role in the maintenance of immune tolerance and the development of silicosis." @default.
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• W2006902212 title "Changes and Significance of CD4+CD25+Foxp3+ regulatory T cells in Peripheral Blood of Rats with Experimental Silicosis" @default.
• W2006902212 doi "https://doi.org/10.1016/j.jaci.2008.01.044" @default.
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