FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006902904> ?p ?o ?g. }

• W2006902904 endingPage "268" @default.
• W2006902904 startingPage "259" @default.
• W2006902904 abstract "The estrogen receptor (ER) exists in two isoforms ERalpha and ERbeta with a different distribution in the body and different functions which are not clearly identified yet. Thus, it is desirable to have both agonists and antagonists with selectivity for one or the other ER isoform available. In a previous study we showed that 2,5-diphenylfurans can be converted into pure antiestrogens with preference for ERalpha. When the arrangement of the phenyl rings was altered to a 2,4-substitution, the alpha-selectivity was lost as demonstrated by comparative assays using recombinant human ERalpha and ERbeta. 3,5-Dialkyl-2,4-bis(4-hydroxyphenylfurans) were shown to act as agonists with preference for ERbeta. Replacement of one of the alkyl groups by the [(pentylsulfanyl)propyl]aminohexyl side chain afforded estrogen antagonists without receptor selectivity. These derivatives were characterized as pure antiestrogens in transcription and proliferation assays in ER+ MCF-7 breast cancer cells. The most potent antagonists displayed IC50 values of ca. 20 nM (fulvestrant 4 nM). The data showed that the 2,4-arrangement of the phenyl rings in the furan structure increases the binding affinity for ERbeta in comparison to the isomeric 2,5-diphenylfurans but does not lead to a pure antagonist with selectivity for ERbeta." @default.
• W2006902904 created "2016-06-24" @default.
• W2006902904 creator A5002543228 @default.
• W2006902904 creator A5046679037 @default.
• W2006902904 date "2007-05-01" @default.
• W2006902904 modified "2023-10-11" @default.
• W2006902904 title "Estrogenic and antiestrogenic activities of 2,4-diphenylfuran-based ligands of estrogen receptors α and β" @default.
• W2006902904 cites W112593876 @default.
• W2006902904 cites W1518317724 @default.
• W2006902904 cites W1967004474 @default.
• W2006902904 cites W1967795733 @default.
• W2006902904 cites W1979535902 @default.
• W2006902904 cites W1979898922 @default.
• W2006902904 cites W1981938678 @default.
• W2006902904 cites W1985414587 @default.
• W2006902904 cites W1988641287 @default.
• W2006902904 cites W1991016211 @default.
• W2006902904 cites W2002957145 @default.
• W2006902904 cites W2042194366 @default.
• W2006902904 cites W2043371605 @default.
• W2006902904 cites W2046011994 @default.
• W2006902904 cites W2051065110 @default.
• W2006902904 cites W2055236011 @default.
• W2006902904 cites W2056155028 @default.
• W2006902904 cites W2059713218 @default.
• W2006902904 cites W2061057693 @default.
• W2006902904 cites W2077655442 @default.
• W2006902904 cites W2085499408 @default.
• W2006902904 cites W2087892362 @default.
• W2006902904 cites W2092411075 @default.
• W2006902904 cites W2101738855 @default.
• W2006902904 cites W2101904881 @default.
• W2006902904 cites W2140084692 @default.
• W2006902904 cites W2151888740 @default.
• W2006902904 cites W2156628023 @default.
• W2006902904 cites W4240866307 @default.
• W2006902904 cites W4293247451 @default.
• W2006902904 doi "https://doi.org/10.1016/j.jsbmb.2007.03.022" @default.
• W2006902904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17475477" @default.
• W2006902904 hasPublicationYear "2007" @default.
• W2006902904 type Work @default.
• W2006902904 sameAs 2006902904 @default.
• W2006902904 citedByCount "15" @default.
• W2006902904 countsByYear W20069029042012 @default.
• W2006902904 countsByYear W20069029042013 @default.
• W2006902904 countsByYear W20069029042014 @default.
• W2006902904 countsByYear W20069029042015 @default.
• W2006902904 countsByYear W20069029042018 @default.
• W2006902904 crossrefType "journal-article" @default.
• W2006902904 hasAuthorship W2006902904A5002543228 @default.
• W2006902904 hasAuthorship W2006902904A5046679037 @default.
• W2006902904 hasConcept C104317684 @default.
• W2006902904 hasConcept C118792377 @default.
• W2006902904 hasConcept C121608353 @default.
• W2006902904 hasConcept C126322002 @default.
• W2006902904 hasConcept C134018914 @default.
• W2006902904 hasConcept C161790260 @default.
• W2006902904 hasConcept C170493617 @default.
• W2006902904 hasConcept C172313692 @default.
• W2006902904 hasConcept C185592680 @default.
• W2006902904 hasConcept C2776067312 @default.
• W2006902904 hasConcept C2776885963 @default.
• W2006902904 hasConcept C2777164284 @default.
• W2006902904 hasConcept C2778938600 @default.
• W2006902904 hasConcept C2780482068 @default.
• W2006902904 hasConcept C530470458 @default.
• W2006902904 hasConcept C53345823 @default.
• W2006902904 hasConcept C55493867 @default.
• W2006902904 hasConcept C71240020 @default.
• W2006902904 hasConcept C71924100 @default.
• W2006902904 hasConcept C84606932 @default.
• W2006902904 hasConcept C86803240 @default.
• W2006902904 hasConcept C96307122 @default.
• W2006902904 hasConcept C98274493 @default.
• W2006902904 hasConceptScore W2006902904C104317684 @default.
• W2006902904 hasConceptScore W2006902904C118792377 @default.
• W2006902904 hasConceptScore W2006902904C121608353 @default.
• W2006902904 hasConceptScore W2006902904C126322002 @default.
• W2006902904 hasConceptScore W2006902904C134018914 @default.
• W2006902904 hasConceptScore W2006902904C161790260 @default.
• W2006902904 hasConceptScore W2006902904C170493617 @default.
• W2006902904 hasConceptScore W2006902904C172313692 @default.
• W2006902904 hasConceptScore W2006902904C185592680 @default.
• W2006902904 hasConceptScore W2006902904C2776067312 @default.
• W2006902904 hasConceptScore W2006902904C2776885963 @default.
• W2006902904 hasConceptScore W2006902904C2777164284 @default.
• W2006902904 hasConceptScore W2006902904C2778938600 @default.
• W2006902904 hasConceptScore W2006902904C2780482068 @default.
• W2006902904 hasConceptScore W2006902904C530470458 @default.
• W2006902904 hasConceptScore W2006902904C53345823 @default.
• W2006902904 hasConceptScore W2006902904C55493867 @default.
• W2006902904 hasConceptScore W2006902904C71240020 @default.
• W2006902904 hasConceptScore W2006902904C71924100 @default.
• W2006902904 hasConceptScore W2006902904C84606932 @default.
• W2006902904 hasConceptScore W2006902904C86803240 @default.
• W2006902904 hasConceptScore W2006902904C96307122 @default.
• W2006902904 hasConceptScore W2006902904C98274493 @default.
• W2006902904 hasIssue "3-5" @default.

• next