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W2006906204 abstract "Lipids influence ergot alkaloid biosynthesis in Claviceps purpurea mainly as structural elements of membranes. Chlorophenoxy acids (CPA) were applied to C. purpurea cultures to modify cellular lipid composition. Mutant strain C. purpurea 59 accumulating tricyclic clavines and two parental strains 35 and 129 were used. All the CPA - clofibrate, 2-(4-chlorophenoxy)-acetate and 2-(4-chlorophenoxy)-propionate (CPP) lowered lipid content. Fatty acid (FA) unsaturation index increased indicating a stimulation of FA-desaturation and also FA-elongation. Sterol biosynthesis was impaired mainly in the C(4)- and C(14)-demethylation resulting in a decrease of “membrane functional” (quasiplanar) sterols. Relative content of phosphatidylethanolamine decreased 1 Of old. Changes in lipids correlated with the decrease of microviscosity of cell membranes (measured as a steady state fluorescence anisotropy of the protoplast membranes with DPH and TMA-DPH as probes). CPP in subtoxic doses stimulated alkaloid production and changed alkaloid composition in the C. purpurea 59 strain impaired in chanoclavine cyclase function." @default.
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W2006906204 date "1990-01-01" @default.
W2006906204 modified "2023-10-17" @default.
W2006906204 title "Regulation of Lipid and Ergot Alkaloid Biosynthesis in Claviceps purpurea by Chlorophenoxy Acids" @default.
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W2006906204 doi "https://doi.org/10.1016/s0015-3796(11)80159-9" @default.
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