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- W2006916434 abstract "We have studied and compared the antinociceptive and anti-hyperalgesic effect of the partial opioid receptor agonist buprenorphine in normal and neuropathic rats. In normal rats, systemic buprenorphine produced dose-dependent antinociception on the hot plate test. In rats with peripheral nerve or spinal cord injury, buprenorphine markedly alleviated neuropathic pain-related behaviors, including mechanical and cold allodynia/hyperalgesia at doses comparable to that producing antinociception. The results suggest that buprenorphine may be a useful analgesic for treating neuropathic pain and thus is an atypical opioid since morphine tends to be less potent after nerve injury." @default.
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- W2006916434 date "2002-08-01" @default.
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- W2006916434 title "Buprenorphine alleviates neuropathic pain-like behaviors in rats after spinal cord and peripheral nerve injury" @default.
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- W2006916434 doi "https://doi.org/10.1016/s0014-2999(02)02052-6" @default.
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