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- W2006921000 abstract "This study investigated the cell apoptosis and gene expression profiles of human THP-1 monocytes in order to identify the molecular mechanism of cell apoptosis induced by meso-2,-3-dimercaptosuccinnic acid-coated Fe 3 O 4 magnetic nanoparticles. Cell apoptosis was visualized with flow cytometry after treated by 50 and 100 μg/ml Fe 3 O 4 nanoparticles, and the gene expression profiles were detected with Affymetrix Human Genome U133 Plus 2.0 GeneChips® microarrays. The transmission electron microscopy obserbation revealed that THP-1 cells were effectively labeled by the Fe 3 O 4 nanoparticles. The internalized Fe 3 O 4 nanoparticles increased cell apoptosis in a dose-dependent manner, but not decreased cell viability significantly. The cDNA microarray results showed that hundreds of genes were significantly regulated at the concentration of 50 and 100 μg/ml, and the level of these genes exhibited a dose response, including CD14 , CD86 , CFLAR , IL-1 , NFKBIA , NLRC4 , NAIP and AIP3 . The Fe 3 O 4 nanoparticles treatments resulted in significantly altered in Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, and Cell apoptosis signaling pathway. Gene ontology analysis of these differentially expressed genes demonstrated that mainly up-regulated genes were related to cytokine production and cell apoptosis. These results showed that the Fe 3 O 4 nanoparticles induced THP-1 cells apoptosis and the level of lots of genes involved in extrinsic apoptosis pathway differentially expressed, which further revealed demonstrated the relation between Fe 3 O 4 MNPs treatment and cell apoptosis." @default.
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- W2006921000 date "2013-08-01" @default.
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- W2006921000 title "Identification of DMSA-Coated Fe<sub>3</sub>O<sub>4</sub> Nanoparticles Induced-Apoptosis Response Genes in Human Monocytes by cDNA Microarrays" @default.
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- W2006921000 doi "https://doi.org/10.4028/www.scientific.net/amr.749.377" @default.
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