Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006937221> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2006937221 endingPage "1779" @default.
- W2006937221 startingPage "1773" @default.
- W2006937221 abstract "Background: Surgical-site infection is a common postoperative nosocomial infection. Surgeons frequently treat operative patients with protective antibiotics and often choose cefazolin as the drug. Treatment schemes include both preoperative intravenous dosing and intraoperative dosing by irrigation. This study was designed to measure cefazolin concentrations both in serum and in wound drain fluid after intravenous dosing and after irrigation. Methods: The authors conducted an institutional review board–approved study involving randomized allocation of breast reduction patients to group 1 (preoperative intravenous dosing) or group 2 (intraoperative dosing by irrigation). Each patient had serum and wound drainage specimens measured over time for cefazolin concentrations. Cefazolin dosing was based on preparations commonly used in the authors’ hospital. Results from 24 patients are reported. Results: Patients treated by conventional preoperative intravenous dosing displayed the expected serum degradation curve. These patients also demonstrated wound drainage concentrations (peak, 22.49 μg/ml) for approximately 4 to 5 hours. Measured concentrations were above the minimum therapeutic concentration (8 μg/ml) for Staphylococcus aureus. Patients treated by wound irrigation also demonstrated serum concentrations above minimum therapeutic concentration. In addition, these patients’ wound drain fluid demonstrated very high cefazolin concentrations (peak, 4185.93 μg/ml), which remained high for 24 hours. Conclusions: Protective cefazolin concentrations in the wound can be achieved by both intravenous and irrigation delivery. Wound irrigation produces higher concentrations for longer periods of time." @default.
- W2006937221 created "2016-06-24" @default.
- W2006937221 creator A5023112237 @default.
- W2006937221 creator A5030734626 @default.
- W2006937221 creator A5045362239 @default.
- W2006937221 creator A5045535190 @default.
- W2006937221 creator A5049475717 @default.
- W2006937221 date "2008-12-01" @default.
- W2006937221 modified "2023-10-14" @default.
- W2006937221 title "Pharmacokinetics of Topical and Intravenous Cefazolin in Patients with Clean Surgical Wounds" @default.
- W2006937221 cites W1491779049 @default.
- W2006937221 cites W1982655236 @default.
- W2006937221 cites W1990414690 @default.
- W2006937221 cites W1997967528 @default.
- W2006937221 cites W2000552558 @default.
- W2006937221 cites W2003503621 @default.
- W2006937221 cites W2032381830 @default.
- W2006937221 cites W2034658664 @default.
- W2006937221 cites W2083100221 @default.
- W2006937221 cites W2133250210 @default.
- W2006937221 cites W2145942332 @default.
- W2006937221 cites W4230133270 @default.
- W2006937221 cites W4231803579 @default.
- W2006937221 cites W4236727544 @default.
- W2006937221 doi "https://doi.org/10.1097/prs.0b013e31818d5899" @default.
- W2006937221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19050530" @default.
- W2006937221 hasPublicationYear "2008" @default.
- W2006937221 type Work @default.
- W2006937221 sameAs 2006937221 @default.
- W2006937221 citedByCount "18" @default.
- W2006937221 countsByYear W20069372212012 @default.
- W2006937221 countsByYear W20069372212015 @default.
- W2006937221 countsByYear W20069372212016 @default.
- W2006937221 countsByYear W20069372212017 @default.
- W2006937221 countsByYear W20069372212018 @default.
- W2006937221 countsByYear W20069372212022 @default.
- W2006937221 crossrefType "journal-article" @default.
- W2006937221 hasAuthorship W2006937221A5023112237 @default.
- W2006937221 hasAuthorship W2006937221A5030734626 @default.
- W2006937221 hasAuthorship W2006937221A5045362239 @default.
- W2006937221 hasAuthorship W2006937221A5045535190 @default.
- W2006937221 hasAuthorship W2006937221A5049475717 @default.
- W2006937221 hasConcept C112705442 @default.
- W2006937221 hasConcept C126322002 @default.
- W2006937221 hasConcept C141071460 @default.
- W2006937221 hasConcept C2777288759 @default.
- W2006937221 hasConcept C2778353156 @default.
- W2006937221 hasConcept C3020304732 @default.
- W2006937221 hasConcept C42219234 @default.
- W2006937221 hasConcept C501593827 @default.
- W2006937221 hasConcept C71924100 @default.
- W2006937221 hasConcept C86803240 @default.
- W2006937221 hasConcept C89423630 @default.
- W2006937221 hasConceptScore W2006937221C112705442 @default.
- W2006937221 hasConceptScore W2006937221C126322002 @default.
- W2006937221 hasConceptScore W2006937221C141071460 @default.
- W2006937221 hasConceptScore W2006937221C2777288759 @default.
- W2006937221 hasConceptScore W2006937221C2778353156 @default.
- W2006937221 hasConceptScore W2006937221C3020304732 @default.
- W2006937221 hasConceptScore W2006937221C42219234 @default.
- W2006937221 hasConceptScore W2006937221C501593827 @default.
- W2006937221 hasConceptScore W2006937221C71924100 @default.
- W2006937221 hasConceptScore W2006937221C86803240 @default.
- W2006937221 hasConceptScore W2006937221C89423630 @default.
- W2006937221 hasIssue "6" @default.
- W2006937221 hasLocation W20069372211 @default.
- W2006937221 hasOpenAccess W2006937221 @default.
- W2006937221 hasPrimaryLocation W20069372211 @default.
- W2006937221 hasRelatedWork W1558414139 @default.
- W2006937221 hasRelatedWork W18383156 @default.
- W2006937221 hasRelatedWork W1898970680 @default.
- W2006937221 hasRelatedWork W1980988043 @default.
- W2006937221 hasRelatedWork W2003503621 @default.
- W2006937221 hasRelatedWork W2006937221 @default.
- W2006937221 hasRelatedWork W2097792791 @default.
- W2006937221 hasRelatedWork W2123960693 @default.
- W2006937221 hasRelatedWork W2409171117 @default.
- W2006937221 hasRelatedWork W2487526680 @default.
- W2006937221 hasVolume "122" @default.
- W2006937221 isParatext "false" @default.
- W2006937221 isRetracted "false" @default.
- W2006937221 magId "2006937221" @default.
- W2006937221 workType "article" @default.