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- W2006940063 abstract "The purpose of this study was to examine the effect of antagonists of different subtypes of Ca(2+) channels (nimodipine and flunarizine) and two types of Ca(2+) chelating agents (the cell permeant Ca(2+) chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N', N'-tetraacetic acid acetoxymethylester (BAPTA-AM) and the cell non-permeant Ca(2+) chelator EGTA) on neurite retraction and cell death of nerve growth factor (NGF)-differentiated PC12 cells after NGF deprivation. We demonstrated that flunarizine and nimodipine, but not BAPTA-AM and EGTA, provided protection against cell death due to NGF deprivation. Using time-lapse videomicroscopy and quantitative image analysis, we found that retraction of neurites was an early and fast phenomenon after removal of NGF. None of the compounds tested (flunarizine, nimodipine, BAPTA-AM, EGTA) could prevent the retraction of neurites." @default.
- W2006940063 created "2016-06-24" @default.
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- W2006940063 date "1999-11-01" @default.
- W2006940063 modified "2023-09-27" @default.
- W2006940063 title "Nimodipine and flunarizine have different effects on survival and morphology of PC12 cells during nerve growth factor deprivation" @default.
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- W2006940063 doi "https://doi.org/10.1016/s0014-2999(99)00665-2" @default.
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