FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006940399> ?p ?o ?g. }

• W2006940399 endingPage "105" @default.
• W2006940399 startingPage "99" @default.
• W2006940399 abstract "Phyllanthus orbicularis is a medicinal plant, endemic to Cuba, whose aqueous extract has proven antiviral properties. This plant extract is being studied for treatment of viral diseases in animals and humans. Antimutagenic activities of this plant aqueous extract have been investigated as an additional and possible valuable property. Antimutagenesis was assayed against the mutagenic activity of m-phenylenediamine (m-PDA), 2-aminofluorene (2-AF), 1-aminopyrene (1-AP), 2-aminoanthracene (2-AA) and 9-aminophenantrene (9-AP) in Salmonella typhimurium (S. typhimurium) YG1024, in different co-treatment approaches. This plant extract produced a significant decrease of the mutagenesis mediated by these aromatic amines (AA) in the following order: m-PDA>2-AA>2-AF>9-AP>1-AP. Interactions with S9 enzymes and transformation of promutagenic amines and their mutagenic metabolites by chemical reactions to non-mutagenic compounds are proposed as possible mechanisms of antimutagenesis. Mutagenesis mediated by m-PDA was almost completely abolished when S9 mixture was co-incubated with the plant extract during 40 min, previous to the addition of the m-PDA and bacterial cells to the assay. Similar results were found with 2-AA and 1-AP, but the reduction of the mutation rate was not so dramatic. In contrast, the most significant antimutagenic effect against 2-AF and 9-AP was seen when these chemicals were co-incubated with the plant extract, before addition of the S9 mixture and bacterial cells to the assay. Therefore, inhibition or competition for S9 enzymes seems to be the main antimutagenic mechanism of this plant extract against m-PDA, 2-AA and 1-AP, whilst a chemical modification of 2-AF and 9-AP into non-promutagenic derivatives is likely to be the main mechanism of antimutagenesis against both compounds." @default.
• W2006940399 created "2016-06-24" @default.
• W2006940399 creator A5005476587 @default.
• W2006940399 creator A5005911335 @default.
• W2006940399 creator A5019118190 @default.
• W2006940399 creator A5025987517 @default.
• W2006940399 creator A5057799350 @default.
• W2006940399 date "2001-11-01" @default.
• W2006940399 modified "2023-10-17" @default.
• W2006940399 title "Studies on the antimutagenesis of Phyllanthus orbicularis: mechanisms involved against aromatic amines" @default.
• W2006940399 cites W107482501 @default.
• W2006940399 cites W1567418909 @default.
• W2006940399 cites W1969023744 @default.
• W2006940399 cites W1974304274 @default.
• W2006940399 cites W1990524419 @default.
• W2006940399 cites W1992017511 @default.
• W2006940399 cites W1996036983 @default.
• W2006940399 cites W2005156172 @default.
• W2006940399 cites W2007034730 @default.
• W2006940399 cites W2017844752 @default.
• W2006940399 cites W2020536246 @default.
• W2006940399 cites W2027215486 @default.
• W2006940399 cites W2034534707 @default.
• W2006940399 cites W2041545351 @default.
• W2006940399 cites W2041823365 @default.
• W2006940399 cites W2043418083 @default.
• W2006940399 cites W2045723173 @default.
• W2006940399 cites W2052549633 @default.
• W2006940399 cites W2054743064 @default.
• W2006940399 cites W2068669380 @default.
• W2006940399 cites W2085786747 @default.
• W2006940399 cites W2086476198 @default.
• W2006940399 cites W2088931089 @default.
• W2006940399 cites W2089790881 @default.
• W2006940399 cites W2090819061 @default.
• W2006940399 cites W2091309341 @default.
• W2006940399 cites W2108006450 @default.
• W2006940399 cites W2115579587 @default.
• W2006940399 cites W2117298514 @default.
• W2006940399 cites W2117900168 @default.
• W2006940399 cites W2133091723 @default.
• W2006940399 cites W2149408776 @default.
• W2006940399 cites W2165090000 @default.
• W2006940399 cites W2167596465 @default.
• W2006940399 cites W2411606507 @default.
• W2006940399 doi "https://doi.org/10.1016/s1383-5718(01)00270-4" @default.
• W2006940399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11673075" @default.
• W2006940399 hasPublicationYear "2001" @default.
• W2006940399 type Work @default.
• W2006940399 sameAs 2006940399 @default.
• W2006940399 citedByCount "23" @default.
• W2006940399 countsByYear W20069403992012 @default.
• W2006940399 countsByYear W20069403992013 @default.
• W2006940399 countsByYear W20069403992014 @default.
• W2006940399 countsByYear W20069403992015 @default.
• W2006940399 countsByYear W20069403992016 @default.
• W2006940399 countsByYear W20069403992018 @default.
• W2006940399 countsByYear W20069403992019 @default.
• W2006940399 countsByYear W20069403992020 @default.
• W2006940399 crossrefType "journal-article" @default.
• W2006940399 hasAuthorship W2006940399A5005476587 @default.
• W2006940399 hasAuthorship W2006940399A5005911335 @default.
• W2006940399 hasAuthorship W2006940399A5019118190 @default.
• W2006940399 hasAuthorship W2006940399A5025987517 @default.
• W2006940399 hasAuthorship W2006940399A5057799350 @default.
• W2006940399 hasConcept C104317684 @default.
• W2006940399 hasConcept C114246631 @default.
• W2006940399 hasConcept C117632636 @default.
• W2006940399 hasConcept C16318435 @default.
• W2006940399 hasConcept C181199279 @default.
• W2006940399 hasConcept C185592680 @default.
• W2006940399 hasConcept C2776639595 @default.
• W2006940399 hasConcept C2776718122 @default.
• W2006940399 hasConcept C2781065037 @default.
• W2006940399 hasConcept C2781422964 @default.
• W2006940399 hasConcept C501734568 @default.
• W2006940399 hasConcept C523546767 @default.
• W2006940399 hasConcept C54355233 @default.
• W2006940399 hasConcept C55493867 @default.
• W2006940399 hasConcept C59822182 @default.
• W2006940399 hasConcept C86803240 @default.
• W2006940399 hasConceptScore W2006940399C104317684 @default.
• W2006940399 hasConceptScore W2006940399C114246631 @default.
• W2006940399 hasConceptScore W2006940399C117632636 @default.
• W2006940399 hasConceptScore W2006940399C16318435 @default.
• W2006940399 hasConceptScore W2006940399C181199279 @default.
• W2006940399 hasConceptScore W2006940399C185592680 @default.
• W2006940399 hasConceptScore W2006940399C2776639595 @default.
• W2006940399 hasConceptScore W2006940399C2776718122 @default.
• W2006940399 hasConceptScore W2006940399C2781065037 @default.
• W2006940399 hasConceptScore W2006940399C2781422964 @default.
• W2006940399 hasConceptScore W2006940399C501734568 @default.
• W2006940399 hasConceptScore W2006940399C523546767 @default.
• W2006940399 hasConceptScore W2006940399C54355233 @default.
• W2006940399 hasConceptScore W2006940399C55493867 @default.
• W2006940399 hasConceptScore W2006940399C59822182 @default.
• W2006940399 hasConceptScore W2006940399C86803240 @default.
• W2006940399 hasIssue "1-2" @default.

• next