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- W2006947960 abstract "Abstract Large research activity has raised around the mechanisms of interaction between extremely low‐frequency magnetic fields (ELF‐MFs) and biological systems. ELF‐MFs may interfere with chemical reactions involving reactive oxygen species (ROS), thus facilitating oxidative damages in living cells. Cortical neurons are particularly susceptible to oxidative stressors and are also highly dependent on the specific factors and proteins governing neuronal development, activity and survival. The aim of the present work was to investigate the effects of exposures to two different 50 Hz sinusoidal ELF‐MFs intensities (0.1 and 1 mT) in maturing rat cortical neurons' major anti‐oxidative enzymatic and non‐enzymatic cellular protection systems, membrane peroxidative damage, as well as growth factor, and cytokine expression pattern. Briefly, our results showed that ELF‐MFs affected positively the cell viability and concomitantly reduced the levels of apoptotic death in rat neuronal primary cultures, with no significant effects on the main anti‐oxidative defences. Interestingly, linear regression analysis suggested a positive correlation between reduced glutathione (GSH) and ROS levels in 1 mT MF‐exposed cells. On this basis, our hypothesis is that GSH could play an important role in the antioxidant defence towards the ELF‐MF‐induced redox challenge. Moreover, the GSH‐based cellular response was achieved together with a brain‐derived neurotrophic factor over‐expression as well as with the interleukin 1β‐dependent regulation of pro‐survival signaling pathways after ELF‐MF exposure. J. Cell. Physiol. 219: 334–343, 2009. © 2008 Wiley‐Liss, Inc." @default.
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- W2006947960 date "2008-12-29" @default.
- W2006947960 modified "2023-10-12" @default.
- W2006947960 title "Fifty hertz extremely low-frequency magnetic field exposure elicits redox and trophic response in rat-cortical neurons" @default.
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- W2006947960 doi "https://doi.org/10.1002/jcp.21674" @default.
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