FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006948882> ?p ?o ?g. }

• W2006948882 endingPage "124" @default.
• W2006948882 startingPage "118" @default.
• W2006948882 abstract "The effects of acute treatment with sibutramine on the peripheral sympathetic neurotransmission in vas deferens of young rats were still not evaluated. Therefore, we carried out this study in order to verify the effects of acute sibutramine treatment on the neuronal- and exogenous agonist-induced contractions of the young rat vas deferens. Young 45-day-old male Wistar rats were pretreated with sibutramine 6 mg/kg and after 4 h the vas deferens was used for experiment. The acute treatment with sibutramine was able to increase the potency (pD2) of noradrenaline and phenylephrine. Moreover, the efficacy (Emax) of noradrenaline was increased while the efficacy of serotonin and nicotine were decreased. The maximum effect induced by a single concentration of tyramine was diminished in the vas deferens from treated group. Moreover, the leftward shift of the noradrenaline curves promoted by uptake blockers (cocaine and corticosterone) and β-adrenoceptor antagonist (propranolol) was reduced in the vas deferens of treated group. The initial phasic and secondary tonic components of the neuronal-evoked contractions of vas deferens from treated group at the frequencies of 2 Hz were decreased. Moreover, only the initial phasic component at 5 Hz was diminished by the acute treatment with sibutramine. In conclusion, we showed that the acute treatment with sibutramine in young rats was able to affect the peripheral sympathetic nervous system by inhibition of noradrenaline uptake and reduction of the neuronal content of this neurotransmitter, leading to an enhancement of vas deferens sensitivity to noradrenaline." @default.
• W2006948882 created "2016-06-24" @default.
• W2006948882 creator A5001723284 @default.
• W2006948882 creator A5029269835 @default.
• W2006948882 creator A5083909780 @default.
• W2006948882 creator A5090165031 @default.
• W2006948882 date "2014-09-01" @default.
• W2006948882 modified "2023-10-03" @default.
• W2006948882 title "Influence of acute treatment with sibutramine on the sympathetic neurotransmission of the young rat vas deferens" @default.
• W2006948882 cites W1497450123 @default.
• W2006948882 cites W1984756020 @default.
• W2006948882 cites W1990267183 @default.
• W2006948882 cites W1990966156 @default.
• W2006948882 cites W1996885375 @default.
• W2006948882 cites W1999349893 @default.
• W2006948882 cites W2001403436 @default.
• W2006948882 cites W2003720934 @default.
• W2006948882 cites W2012892796 @default.
• W2006948882 cites W2015497163 @default.
• W2006948882 cites W2015992580 @default.
• W2006948882 cites W2017853801 @default.
• W2006948882 cites W2020764641 @default.
• W2006948882 cites W2021997881 @default.
• W2006948882 cites W2050933076 @default.
• W2006948882 cites W2053424252 @default.
• W2006948882 cites W2053591832 @default.
• W2006948882 cites W2054371063 @default.
• W2006948882 cites W2056248768 @default.
• W2006948882 cites W2060157239 @default.
• W2006948882 cites W2061696440 @default.
• W2006948882 cites W2065419848 @default.
• W2006948882 cites W2071988467 @default.
• W2006948882 cites W2086335136 @default.
• W2006948882 cites W2086577238 @default.
• W2006948882 cites W2086786574 @default.
• W2006948882 cites W2087957781 @default.
• W2006948882 cites W2101364435 @default.
• W2006948882 cites W2105981664 @default.
• W2006948882 cites W2115519984 @default.
• W2006948882 cites W2119754700 @default.
• W2006948882 cites W2126189268 @default.
• W2006948882 cites W2166047249 @default.
• W2006948882 doi "https://doi.org/10.1016/j.ejphar.2014.05.035" @default.
• W2006948882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24886880" @default.
• W2006948882 hasPublicationYear "2014" @default.
• W2006948882 type Work @default.
• W2006948882 sameAs 2006948882 @default.
• W2006948882 citedByCount "4" @default.
• W2006948882 countsByYear W20069488822015 @default.
• W2006948882 countsByYear W20069488822017 @default.
• W2006948882 countsByYear W20069488822018 @default.
• W2006948882 countsByYear W20069488822022 @default.
• W2006948882 crossrefType "journal-article" @default.
• W2006948882 hasAuthorship W2006948882A5001723284 @default.
• W2006948882 hasAuthorship W2006948882A5029269835 @default.
• W2006948882 hasAuthorship W2006948882A5083909780 @default.
• W2006948882 hasAuthorship W2006948882A5090165031 @default.
• W2006948882 hasBestOaLocation W20069488821 @default.
• W2006948882 hasConcept C126322002 @default.
• W2006948882 hasConcept C134018914 @default.
• W2006948882 hasConcept C170493617 @default.
• W2006948882 hasConcept C2775864247 @default.
• W2006948882 hasConcept C2776219046 @default.
• W2006948882 hasConcept C2777646958 @default.
• W2006948882 hasConcept C2777952589 @default.
• W2006948882 hasConcept C2778210472 @default.
• W2006948882 hasConcept C42219234 @default.
• W2006948882 hasConcept C511355011 @default.
• W2006948882 hasConcept C529278444 @default.
• W2006948882 hasConcept C544821477 @default.
• W2006948882 hasConcept C71924100 @default.
• W2006948882 hasConcept C84393581 @default.
• W2006948882 hasConceptScore W2006948882C126322002 @default.
• W2006948882 hasConceptScore W2006948882C134018914 @default.
• W2006948882 hasConceptScore W2006948882C170493617 @default.
• W2006948882 hasConceptScore W2006948882C2775864247 @default.
• W2006948882 hasConceptScore W2006948882C2776219046 @default.
• W2006948882 hasConceptScore W2006948882C2777646958 @default.
• W2006948882 hasConceptScore W2006948882C2777952589 @default.
• W2006948882 hasConceptScore W2006948882C2778210472 @default.
• W2006948882 hasConceptScore W2006948882C42219234 @default.
• W2006948882 hasConceptScore W2006948882C511355011 @default.
• W2006948882 hasConceptScore W2006948882C529278444 @default.
• W2006948882 hasConceptScore W2006948882C544821477 @default.
• W2006948882 hasConceptScore W2006948882C71924100 @default.
• W2006948882 hasConceptScore W2006948882C84393581 @default.
• W2006948882 hasFunder F4320320997 @default.
• W2006948882 hasFunder F4320321091 @default.
• W2006948882 hasFunder F4320322025 @default.
• W2006948882 hasLocation W20069488821 @default.
• W2006948882 hasLocation W20069488822 @default.
• W2006948882 hasOpenAccess W2006948882 @default.
• W2006948882 hasPrimaryLocation W20069488821 @default.
• W2006948882 hasRelatedWork W1558342319 @default.
• W2006948882 hasRelatedWork W2006948882 @default.
• W2006948882 hasRelatedWork W2027622212 @default.
• W2006948882 hasRelatedWork W2027834137 @default.
• W2006948882 hasRelatedWork W2038221598 @default.

• next