FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006956708> ?p ?o ?g. }

• W2006956708 endingPage "e108514" @default.
• W2006956708 startingPage "e108514" @default.
• W2006956708 abstract "Chemotherapeutic drug resistance and relapse remains a major challenge for paediatric (medulloblastoma) and adult (glioblastoma) brain tumour treatment. Medulloblastoma tumours and cell lines with mutations in the p53 signalling pathway have been shown to be specifically insensitive to DNA damaging agents. The aim of this study was to investigate the potential of triggering cell death in p53 mutated medulloblastoma cells by a direct activation of pro-death signalling downstream of p53 activation. Since non-coding microRNAs (miRNAs) have the ability to fine tune the expression of a variety of target genes, orchestrating multiple downstream effects, we hypothesised that triggering the expression of a p53 target miRNA could induce cell death in chemo-resistant cells. Treatment with etoposide, increased miR-34a levels in a p53-dependent fashion and the level of miR-34a transcription was correlated with the cell sensitivity to etoposide. miR-34a activity was validated by measuring the expression levels of one of its well described target: the NADH dependent sirtuin1 (SIRT1). Whilst drugs directly targeting SIRT1, were potent to trigger cell death at high concentrations only, introduction of synthetic miR-34a mimics was able to induce cell death in p53 mutated medulloblastoma and glioblastoma cell lines. Our results show that the need of a functional p53 signaling pathway can be bypassed by direct activation of miR-34a in brain tumour cells." @default.
• W2006956708 created "2016-06-24" @default.
• W2006956708 creator A5024168752 @default.
• W2006956708 creator A5026035536 @default.
• W2006956708 creator A5053745730 @default.
• W2006956708 creator A5058756218 @default.
• W2006956708 date "2014-09-24" @default.
• W2006956708 modified "2023-10-16" @default.
• W2006956708 title "Mir-34a Mimics Are Potential Therapeutic Agents for p53-Mutated and Chemo-Resistant Brain Tumour Cells" @default.
• W2006956708 cites W144423133 @default.
• W2006956708 cites W1565787954 @default.
• W2006956708 cites W1920303762 @default.
• W2006956708 cites W1966116761 @default.
• W2006956708 cites W1982789849 @default.
• W2006956708 cites W1985563073 @default.
• W2006956708 cites W1990258390 @default.
• W2006956708 cites W1994455902 @default.
• W2006956708 cites W1996423090 @default.
• W2006956708 cites W1996711379 @default.
• W2006956708 cites W2000904576 @default.
• W2006956708 cites W2001140923 @default.
• W2006956708 cites W2006173503 @default.
• W2006956708 cites W2007326142 @default.
• W2006956708 cites W2008257691 @default.
• W2006956708 cites W2008887283 @default.
• W2006956708 cites W2022621311 @default.
• W2006956708 cites W2026099724 @default.
• W2006956708 cites W2031475327 @default.
• W2006956708 cites W2036005496 @default.
• W2006956708 cites W2037114802 @default.
• W2006956708 cites W2049942970 @default.
• W2006956708 cites W2059848983 @default.
• W2006956708 cites W2063589273 @default.
• W2006956708 cites W2074210527 @default.
• W2006956708 cites W2074766088 @default.
• W2006956708 cites W2079843575 @default.
• W2006956708 cites W2080084006 @default.
• W2006956708 cites W2084815426 @default.
• W2006956708 cites W2092658747 @default.
• W2006956708 cites W2092728526 @default.
• W2006956708 cites W2102144501 @default.
• W2006956708 cites W2102441837 @default.
• W2006956708 cites W2103988492 @default.
• W2006956708 cites W2109155259 @default.
• W2006956708 cites W2119976307 @default.
• W2006956708 cites W2122785662 @default.
• W2006956708 cites W2127643721 @default.
• W2006956708 cites W2129331946 @default.
• W2006956708 cites W2136877233 @default.
• W2006956708 cites W2138546316 @default.
• W2006956708 cites W2141738919 @default.
• W2006956708 cites W2147730829 @default.
• W2006956708 cites W2150494811 @default.
• W2006956708 cites W2158266975 @default.
• W2006956708 cites W2162667797 @default.
• W2006956708 cites W2163101559 @default.
• W2006956708 cites W2166636120 @default.
• W2006956708 cites W2170501066 @default.
• W2006956708 doi "https://doi.org/10.1371/journal.pone.0108514" @default.
• W2006956708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4177398" @default.
• W2006956708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25250818" @default.
• W2006956708 hasPublicationYear "2014" @default.
• W2006956708 type Work @default.
• W2006956708 sameAs 2006956708 @default.
• W2006956708 citedByCount "31" @default.
• W2006956708 countsByYear W20069567082014 @default.
• W2006956708 countsByYear W20069567082015 @default.
• W2006956708 countsByYear W20069567082016 @default.
• W2006956708 countsByYear W20069567082017 @default.
• W2006956708 countsByYear W20069567082018 @default.
• W2006956708 countsByYear W20069567082019 @default.
• W2006956708 countsByYear W20069567082020 @default.
• W2006956708 countsByYear W20069567082021 @default.
• W2006956708 countsByYear W20069567082022 @default.
• W2006956708 countsByYear W20069567082023 @default.
• W2006956708 crossrefType "journal-article" @default.
• W2006956708 hasAuthorship W2006956708A5024168752 @default.
• W2006956708 hasAuthorship W2006956708A5026035536 @default.
• W2006956708 hasAuthorship W2006956708A5053745730 @default.
• W2006956708 hasAuthorship W2006956708A5058756218 @default.
• W2006956708 hasBestOaLocation W20069567081 @default.
• W2006956708 hasConcept C104317684 @default.
• W2006956708 hasConcept C143425029 @default.
• W2006956708 hasConcept C145059251 @default.
• W2006956708 hasConcept C190283241 @default.
• W2006956708 hasConcept C2776694085 @default.
• W2006956708 hasConcept C2778119113 @default.
• W2006956708 hasConcept C2780789225 @default.
• W2006956708 hasConcept C31573885 @default.
• W2006956708 hasConcept C502942594 @default.
• W2006956708 hasConcept C54355233 @default.
• W2006956708 hasConcept C552990157 @default.
• W2006956708 hasConcept C62112901 @default.
• W2006956708 hasConcept C81885089 @default.
• W2006956708 hasConcept C86803240 @default.
• W2006956708 hasConceptScore W2006956708C104317684 @default.
• W2006956708 hasConceptScore W2006956708C143425029 @default.
• W2006956708 hasConceptScore W2006956708C145059251 @default.

• next