Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006959392> ?p ?o ?g. }
- W2006959392 endingPage "361" @default.
- W2006959392 startingPage "347" @default.
- W2006959392 abstract "Objective Lithium (Li) is often an effective treatment for mood disorders, especially bipolar disorder (BPD), and can mitigate the effects of stress on the brain by modulating several pathways to facilitate neural plasticity. This review seeks to summarize what is known about the molecular mechanisms underlying Li's actions in the brain in response to stress, particularly how Li is able to facilitate plasticity through regulation of the glutamate system and cytoskeletal components. Method The authors conducted an extensive search of the published literature using several search terms, including Li, plasticity, and stress. Relevant articles were retrieved, and their bibliographies consulted to expand the number of articles reviewed. The most relevant articles from both the clinical and preclinical literature were examined in detail. Results Chronic stress results in morphological and functional remodeling in specific brain regions where structural differences have been associated with mood disorders, such as BPD. Li has been shown to block stress-induced changes and facilitate neural plasticity. The onset of mood disorders may reflect an inability of the brain to properly respond after stress, where changes in certain regions may become ‘locked in’ when plasticity is lost. Li can enhance plasticity through several molecular mechanisms, which have been characterized in animal models. Further, the expanding number of clinical imaging studies has provided evidence that these mechanisms may be at work in the human brain. Conclusion This work supports the hypothesis that Li is able to improve clinical symptoms by facilitating neural plasticity and thereby helps to ‘unlock’ the brain from its maladaptive state in patients with mood disorders." @default.
- W2006959392 created "2016-06-24" @default.
- W2006959392 creator A5035103174 @default.
- W2006959392 creator A5037655386 @default.
- W2006959392 date "2013-04-26" @default.
- W2006959392 modified "2023-10-18" @default.
- W2006959392 title "Lithium's role in neural plasticity and its implications for mood disorders" @default.
- W2006959392 cites W1480120703 @default.
- W2006959392 cites W1530114072 @default.
- W2006959392 cites W1584789181 @default.
- W2006959392 cites W1625103160 @default.
- W2006959392 cites W1642124290 @default.
- W2006959392 cites W1784693460 @default.
- W2006959392 cites W1897439129 @default.
- W2006959392 cites W1963600261 @default.
- W2006959392 cites W1965143003 @default.
- W2006959392 cites W1968859203 @default.
- W2006959392 cites W1969412681 @default.
- W2006959392 cites W1974369164 @default.
- W2006959392 cites W1974514009 @default.
- W2006959392 cites W1975745455 @default.
- W2006959392 cites W1976822415 @default.
- W2006959392 cites W1977118330 @default.
- W2006959392 cites W1978341502 @default.
- W2006959392 cites W1979563893 @default.
- W2006959392 cites W1979993283 @default.
- W2006959392 cites W1980129105 @default.
- W2006959392 cites W1980653339 @default.
- W2006959392 cites W1981420391 @default.
- W2006959392 cites W1982844998 @default.
- W2006959392 cites W1983775664 @default.
- W2006959392 cites W1984120803 @default.
- W2006959392 cites W1984797214 @default.
- W2006959392 cites W1988993555 @default.
- W2006959392 cites W1989014374 @default.
- W2006959392 cites W1989809732 @default.
- W2006959392 cites W1990212220 @default.
- W2006959392 cites W1990948522 @default.
- W2006959392 cites W1991512531 @default.
- W2006959392 cites W1991717721 @default.
- W2006959392 cites W1992364331 @default.
- W2006959392 cites W1992657184 @default.
- W2006959392 cites W1993385893 @default.
- W2006959392 cites W1995907546 @default.
- W2006959392 cites W1997052372 @default.
- W2006959392 cites W1997093700 @default.
- W2006959392 cites W2000388202 @default.
- W2006959392 cites W2002623292 @default.
- W2006959392 cites W2003432290 @default.
- W2006959392 cites W2004850661 @default.
- W2006959392 cites W2007636259 @default.
- W2006959392 cites W2007719377 @default.
- W2006959392 cites W2008301967 @default.
- W2006959392 cites W2008620918 @default.
- W2006959392 cites W2014381681 @default.
- W2006959392 cites W2015204304 @default.
- W2006959392 cites W2016950757 @default.
- W2006959392 cites W2017440002 @default.
- W2006959392 cites W2017546083 @default.
- W2006959392 cites W2020291601 @default.
- W2006959392 cites W2020977183 @default.
- W2006959392 cites W2022221011 @default.
- W2006959392 cites W2024493236 @default.
- W2006959392 cites W2024709318 @default.
- W2006959392 cites W2024821272 @default.
- W2006959392 cites W2026102869 @default.
- W2006959392 cites W2027397876 @default.
- W2006959392 cites W2029406839 @default.
- W2006959392 cites W2030156843 @default.
- W2006959392 cites W2031088130 @default.
- W2006959392 cites W2031361714 @default.
- W2006959392 cites W2031598294 @default.
- W2006959392 cites W2032096407 @default.
- W2006959392 cites W2032194434 @default.
- W2006959392 cites W2032594882 @default.
- W2006959392 cites W2033456614 @default.
- W2006959392 cites W2035172439 @default.
- W2006959392 cites W2036037610 @default.
- W2006959392 cites W2036687775 @default.
- W2006959392 cites W2036956901 @default.
- W2006959392 cites W2037060007 @default.
- W2006959392 cites W2037630410 @default.
- W2006959392 cites W2037962204 @default.
- W2006959392 cites W2038084705 @default.
- W2006959392 cites W2044220354 @default.
- W2006959392 cites W2047055042 @default.
- W2006959392 cites W2048335778 @default.
- W2006959392 cites W2048966304 @default.
- W2006959392 cites W2051715358 @default.
- W2006959392 cites W2051788298 @default.
- W2006959392 cites W2053766206 @default.
- W2006959392 cites W2053842655 @default.
- W2006959392 cites W2054148524 @default.
- W2006959392 cites W2054500214 @default.
- W2006959392 cites W2054851762 @default.
- W2006959392 cites W2058138221 @default.
- W2006959392 cites W2060973139 @default.
- W2006959392 cites W2062746952 @default.