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- W2006993312 abstract "Before DNA replication can be initiated a definite number of adenosine triphosphate (ATP) containing pre-replication protein complexes (pre-RCs) must be assembled and bound to DNA like in a super-critical mass. A chemically driven dynamics of the Ginzburg-Landau (GL) type is derived, using the non-equilibrium equation for binding of pre-RCs to DNA and a probabilistic conformational distribution of these protein complexes. This dynamics, in which the DNA-protein system behaves like a nonlinear elastically braced string (NEBS), can control the cell cycle via conformational transitions such that G2 cells contain exactly twice as much DNA as G1 cells. After adjustment of previously-made derivations, the model is compared with cell growth data from the T lymphocyte MLA-144." @default.
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- W2006993312 date "2005-12-01" @default.
- W2006993312 modified "2023-09-23" @default.
- W2006993312 title "Model of DNA Dynamics and Replication" @default.
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- W2006993312 doi "https://doi.org/10.1007/s10867-005-4635-1" @default.
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