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- W2006995807 abstract "Myelin proteolipid protein (PLP) contains one established antigenic epitope within the 131–151 amino acid sequence, with encephalitogenic activity for SJL mice (PLP139-151). In the current study, the processing and presentation of PLP by subsets of splenic antigen-presenting cells (APC) were examined by comparing their capacity to stimulate PLP-responsive T-cell clones, two of which are specific for PLP139-151, and one which is not specific for this peptide. In order to study whether PLP requires processing before its presentation by APC, PLP-pulsed and fixed APC were shown to stimulate PLP-specific T cells. However, the addition of PLP to unpulsed, fixed APC resulted in the absence of T-cell stimulation, while the ability of these fixed APC to bind antigenic peptide and efficiently present it to T cells, was demonstrated by their ability to use a synthetic peptide for the stimulation of the T cells. In order to study potentially different processing efficiencies among APC subsets, spleen cells were fractionated by adherence to plastic, and their respective APC activities were studied separately. The non-adherent (NAd) APC were unable to stimulate PLP139-151 specific T-cell clones with PLP as antigen. In contrast, a T-cell clone specific for a separate, but unidentified epitope on PLP was stimulated by NAd APC efficiently. In addition, stimulation of PLP139-151-specific T-cell clones by NAd APC did occur when the synthetic peptide instead of intact PLP was used as antigen, indicating a defect in PLP processing by the NAd APC. These results indicate that a subpopulation of splenic APC is unable to process PLP efficiently, and more specifically, may be unable to process a fragment containing the 139–151 sequence in PLP, while other antigenic fragments may be processed and subsequently presented efficiently." @default.
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- W2006995807 date "1992-05-01" @default.
- W2006995807 modified "2023-10-17" @default.
- W2006995807 title "Immune processing of proteolipid protein by subsets of antigen-presenting spleen cells" @default.
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- W2006995807 doi "https://doi.org/10.1016/0165-5728(92)90098-6" @default.
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