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- W2006997029 abstract "Rat adipocytes were incubated with 15 nM insulin in different buffers at 37°C. The cells were washed and reincubated at 16°C in the presence of 18 pM A14-[125I]monoiodoinsulin to determine the insulin receptor concentration. After incubation for 2 h in Tris buffer the binding decreased to about 30 %, whereas no decrease was found after incubation in Hepes, phosphate or bicarbonate buffers. Binding of tracer insulin reached a constant level by 45 min in Hepes buffer at 37°C, whereas it continued to increase in Tris buffer. Washout of tracer insulin after incubation in Tris buffer at 37°C showed a large, slowly dissociable fraction. It is suggested that the rapid down regulation of insulin receptors invitro is an artifact of the Tris buffer and that the phenomenon is due to a slowly reversible occupancy of a receptor pool with unlabelled insulin." @default.
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- W2006997029 date "1981-10-01" @default.
- W2006997029 modified "2023-10-14" @default.
- W2006997029 title "Rapid down regulation of insulin receptors in adipocytes artifact of the incubation buffer" @default.
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- W2006997029 doi "https://doi.org/10.1016/0006-291x(81)91612-0" @default.
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