Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007002034> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2007002034 endingPage "851" @default.
- W2007002034 startingPage "846" @default.
- W2007002034 abstract "We determined the nucleotide sequence of the VL and VH regions of four human monoclonal IgM directed to myelin-associated glycoprotein (MAG) and a nerve glycolipid, the sulfated glucuronic paragloboside (SGPG). Clonal lymphoblastoid cell lines (three cases) and an heterohybridoma (one case) secreting anti-MAG IgM were derived from patients' blood B cells. V kappa genes derived from the single germinal V kappa IV (two cases), the V kappa Id and the V kappa IIIa Humkv328h5 genes. VH genes derived from the VHIII 9.1 germinal gene (or a closely related gene) in two cases, whereas two others possibly represent new members of the VHIII or VHI variability subgroups. There was no obvious restriction in the use of J kappa, JH and DH segments. Somatic mutations were predominantly found in the CDR3 of the V kappa IV genes with an overall ratio of replacement over silent mutations of 7/0. The sequence of two VHIII genes exhibited five replacement mutations in CDR in comparison to that of the germ-line 9.1 gene. Although some V genes are likely to be overrepresented among anti-MAG IgM, the diversity of the immune repertoire for MAG and SGPG explains the lack of easily detectable public idiotopes among these IgM. This last finding, as well as a high ratio of replacement versus silent nucleotide mutations in the CDR of VL and probably VH genes, suggest that the pathogenesis of these monoclonal antibodies (and of the associated lymphoplasmocytic disorder) differs from that of other previously characterized monoclonal autoantibodies such as rheumatoid factors and cold agglutinins." @default.
- W2007002034 created "2016-06-24" @default.
- W2007002034 creator A5014394590 @default.
- W2007002034 creator A5051196993 @default.
- W2007002034 creator A5061881019 @default.
- W2007002034 date "1993-04-01" @default.
- W2007002034 modified "2023-09-27" @default.
- W2007002034 title "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein" @default.
- W2007002034 cites W1501882824 @default.
- W2007002034 cites W1546739249 @default.
- W2007002034 cites W161233626 @default.
- W2007002034 cites W1667877556 @default.
- W2007002034 cites W176908954 @default.
- W2007002034 cites W1972884489 @default.
- W2007002034 cites W1977993700 @default.
- W2007002034 cites W1980414801 @default.
- W2007002034 cites W1994590517 @default.
- W2007002034 cites W2010587966 @default.
- W2007002034 cites W2013325112 @default.
- W2007002034 cites W2030620813 @default.
- W2007002034 cites W2036050361 @default.
- W2007002034 cites W2048517624 @default.
- W2007002034 cites W2051705220 @default.
- W2007002034 cites W2052369653 @default.
- W2007002034 cites W2060333964 @default.
- W2007002034 cites W2063450941 @default.
- W2007002034 cites W2070814047 @default.
- W2007002034 cites W2084323558 @default.
- W2007002034 cites W2095444411 @default.
- W2007002034 cites W2098252493 @default.
- W2007002034 cites W2122411338 @default.
- W2007002034 cites W2135151085 @default.
- W2007002034 cites W2138270253 @default.
- W2007002034 cites W2139342994 @default.
- W2007002034 cites W2140240512 @default.
- W2007002034 cites W2156320314 @default.
- W2007002034 doi "https://doi.org/10.1002/eji.1830230412" @default.
- W2007002034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7681398" @default.
- W2007002034 hasPublicationYear "1993" @default.
- W2007002034 type Work @default.
- W2007002034 sameAs 2007002034 @default.
- W2007002034 citedByCount "17" @default.
- W2007002034 crossrefType "journal-article" @default.
- W2007002034 hasAuthorship W2007002034A5014394590 @default.
- W2007002034 hasAuthorship W2007002034A5051196993 @default.
- W2007002034 hasAuthorship W2007002034A5061881019 @default.
- W2007002034 hasConcept C104317684 @default.
- W2007002034 hasConcept C153911025 @default.
- W2007002034 hasConcept C159654299 @default.
- W2007002034 hasConcept C163864487 @default.
- W2007002034 hasConcept C169760540 @default.
- W2007002034 hasConcept C203014093 @default.
- W2007002034 hasConcept C2778609137 @default.
- W2007002034 hasConcept C529278444 @default.
- W2007002034 hasConcept C542903549 @default.
- W2007002034 hasConcept C54355233 @default.
- W2007002034 hasConcept C8162170 @default.
- W2007002034 hasConcept C86803240 @default.
- W2007002034 hasConceptScore W2007002034C104317684 @default.
- W2007002034 hasConceptScore W2007002034C153911025 @default.
- W2007002034 hasConceptScore W2007002034C159654299 @default.
- W2007002034 hasConceptScore W2007002034C163864487 @default.
- W2007002034 hasConceptScore W2007002034C169760540 @default.
- W2007002034 hasConceptScore W2007002034C203014093 @default.
- W2007002034 hasConceptScore W2007002034C2778609137 @default.
- W2007002034 hasConceptScore W2007002034C529278444 @default.
- W2007002034 hasConceptScore W2007002034C542903549 @default.
- W2007002034 hasConceptScore W2007002034C54355233 @default.
- W2007002034 hasConceptScore W2007002034C8162170 @default.
- W2007002034 hasConceptScore W2007002034C86803240 @default.
- W2007002034 hasIssue "4" @default.
- W2007002034 hasLocation W20070020341 @default.
- W2007002034 hasLocation W20070020342 @default.
- W2007002034 hasOpenAccess W2007002034 @default.
- W2007002034 hasPrimaryLocation W20070020341 @default.
- W2007002034 hasRelatedWork W1971294201 @default.
- W2007002034 hasRelatedWork W1999686187 @default.
- W2007002034 hasRelatedWork W2025678534 @default.
- W2007002034 hasRelatedWork W2036403810 @default.
- W2007002034 hasRelatedWork W2073840950 @default.
- W2007002034 hasRelatedWork W2146940419 @default.
- W2007002034 hasRelatedWork W2361454127 @default.
- W2007002034 hasRelatedWork W2366047017 @default.
- W2007002034 hasRelatedWork W2368460920 @default.
- W2007002034 hasRelatedWork W2380360044 @default.
- W2007002034 hasVolume "23" @default.
- W2007002034 isParatext "false" @default.
- W2007002034 isRetracted "false" @default.
- W2007002034 magId "2007002034" @default.
- W2007002034 workType "article" @default.