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- W2007003313 abstract "Aquaporin 4 (AQP4) is abundantly expressed in the perivascular glial endfeet in the central nervous system (CNS), where it is involved in the exchange of fluids between blood and brain. At this location, AQP4 contributes to the formation and/or the absorption of the brain edema that may arise following pathologies such as brain injuries, brain tumours, and cerebral ischemia. As vasopressin and its G-protein-coupled receptor (V1(a)R) have been shown to affect the outcome of brain edema, we have investigated the regulatory interaction between AQP4 and V1(a)R by heterologous expression in Xenopus laevis oocytes. The water permeability of AQP4/V1(a)R-expressing oocytes was reduced in a vasopressin-dependent manner, as a result of V1(a)R-dependent internalization of AQP4. Vasopressin-dependent internalization was not observed in AQP9/V1(a)R-expressing oocytes. The regulatory interaction between AQP4 and V1(a)R involves protein kinase C (PKC) activation and is reduced upon mutation of Ser(180) on AQP4 to an alanine. Thus, the present study demonstrates at the molecular level a functional link between the vasopressin receptor V1(a)R and AQP4. This functional interaction between AQP4 and V1(a)R may prove to be a potential therapeutic target in the prevention and treatment of brain edema." @default.
- W2007003313 created "2016-06-24" @default.
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- W2007003313 date "2009-12-01" @default.
- W2007003313 modified "2023-10-08" @default.
- W2007003313 title "Vasopressin-dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes" @default.
- W2007003313 cites W122196867 @default.
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- W2007003313 cites W1535419310 @default.
- W2007003313 cites W1539041562 @default.
- W2007003313 cites W1570517521 @default.
- W2007003313 cites W1591974057 @default.
- W2007003313 cites W1595184644 @default.
- W2007003313 cites W172954148 @default.
- W2007003313 cites W1945275845 @default.
- W2007003313 cites W1963614683 @default.
- W2007003313 cites W1963655920 @default.
- W2007003313 cites W1967096577 @default.
- W2007003313 cites W1970305997 @default.
- W2007003313 cites W1971931351 @default.
- W2007003313 cites W1972389227 @default.
- W2007003313 cites W1974073362 @default.
- W2007003313 cites W1975002799 @default.
- W2007003313 cites W1980085014 @default.
- W2007003313 cites W1980829307 @default.
- W2007003313 cites W1982496656 @default.
- W2007003313 cites W1984587620 @default.
- W2007003313 cites W1987617633 @default.
- W2007003313 cites W1987781885 @default.
- W2007003313 cites W1993054081 @default.
- W2007003313 cites W1996462589 @default.
- W2007003313 cites W2000760680 @default.
- W2007003313 cites W2004218762 @default.
- W2007003313 cites W2012459072 @default.
- W2007003313 cites W2016551781 @default.
- W2007003313 cites W2022562192 @default.
- W2007003313 cites W2023735422 @default.
- W2007003313 cites W2024630363 @default.
- W2007003313 cites W2031275782 @default.
- W2007003313 cites W2036739822 @default.
- W2007003313 cites W2037984086 @default.
- W2007003313 cites W2040733706 @default.
- W2007003313 cites W2041615248 @default.
- W2007003313 cites W2052070303 @default.
- W2007003313 cites W2053912441 @default.
- W2007003313 cites W2057509573 @default.
- W2007003313 cites W2059149362 @default.
- W2007003313 cites W2068005044 @default.
- W2007003313 cites W2072076252 @default.
- W2007003313 cites W2073258874 @default.
- W2007003313 cites W2074930937 @default.
- W2007003313 cites W2084304818 @default.
- W2007003313 cites W2088753460 @default.
- W2007003313 cites W2089450477 @default.
- W2007003313 cites W2094566223 @default.
- W2007003313 cites W2097182515 @default.
- W2007003313 cites W2098732711 @default.
- W2007003313 cites W2100564861 @default.
- W2007003313 cites W2105803104 @default.
- W2007003313 cites W2109603606 @default.
- W2007003313 cites W2111964398 @default.
- W2007003313 cites W2118687598 @default.
- W2007003313 cites W2120679080 @default.
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- W2007003313 cites W2133048623 @default.
- W2007003313 cites W2138684097 @default.
- W2007003313 cites W2142464706 @default.
- W2007003313 cites W2144324490 @default.
- W2007003313 cites W2148556363 @default.
- W2007003313 cites W2153376408 @default.
- W2007003313 cites W2155855405 @default.
- W2007003313 cites W2156050966 @default.
- W2007003313 cites W2156403214 @default.
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- W2007003313 doi "https://doi.org/10.1016/j.neuroscience.2009.09.072" @default.
- W2007003313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19800950" @default.
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