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- W2007003974 abstract "O carcinoma medular de tireóide (CMT) pode ocorrer na forma esporádica ou familiar. O CMT hereditário é parte das síndromes de neoplasia endócrina múltipla (NEM) 2A e 2B, carcinoma medular de tireóide familiar (CMTF) ou outras formas. Mutações de linhagem germinativa do proto-oncogene RET causam a forma hereditária da neoplasia e os testes genéticos atualmente disponíveis formam a base para o manejo adequado da hereditariedade do tumor, visto que o diagnóstico precoce melhora significativamente o prognóstico no indivíduo afetado e nos carreadores. Nos últimos anos, vários estudos têm demonstrado uma correlação entre mutações codon-específica do RET e os diferentes fenótipos da NEM 2A, que pode, em parte, ser explicada por diferenças na intensidade da indução da dimerização do receptor. No presente artigo, revisamos os avanços nos mecanismos moleculares, diagnóstico e tratamento, bem como relatamos a nossa experiência no manejo dessa forma rara de neoplasia tireoidiana." @default.
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- W2007003974 date "2004-02-01" @default.
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- W2007003974 title "Carcinoma medular de tireóide: aspectos moleculares, clínico-oncológicos e terapêuticos" @default.
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- W2007003974 doi "https://doi.org/10.1590/s0004-27302004000100015" @default.
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