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- W2007005005 abstract "Study Objective: To evaluate the effect of tamoxifen(TAM) on the endometrium and to elaborate a strategy of endometrial follow-up for premenopausal or menopausal women treated with tamoxifen as adjuvant hormonal treatment for postoperative breast cancer women. Design: Retrospectively analysed 150 patients, who were treated with TAM and admitted to our gynecologic ward because of their pelvic problems. Setting: Peking University First Hospital. Patients: Premenopausal or menopausal patients, who were treated with TAM in for postoperative breast cancer from January 1993 to August 2008. Measurements and Main Results: Ten (10/53,18.9%) patients in the premenopausal group had endometrial or endocervical polyps, hyperplasia, and endometrioid carcinoma, where as 49 cases (49/97, 50.5%) in the menopausal group developed these diseases, P<0.001. All the atypical hyperplasia and endometrioid carcinoma cases occurred in menopausal group. Risk factors of endometrial diseases were associated with menopause and abnormal vaginal bleeding, but no more relationship with the duration and dosage of tamoxifen. Conclusion: It is very important to pay more attention on postmenopausal woman who taking tamoxifen after her operation of breast cancer, and we suggested more care for postmenopausal tamoxifen taking women, including before and/or during tamoxifen usage." @default.
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- W2007005005 date "2010-11-01" @default.
- W2007005005 modified "2023-09-23" @default.
- W2007005005 title "150 Cases Clinical and Pathology Analysis about Tamoxifen on Endometrial Lesions" @default.
- W2007005005 doi "https://doi.org/10.1016/j.jmig.2010.08.584" @default.
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