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- W2007014682 abstract "There is a mutualistic symbiotic relationship between the components of the photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris (CC) complex that is lost in AMD. Which component in the photoreceptor/RPE/BrMb/CC complex is affected first appears to depend on the type of AMD. In atrophic AMD (~85-90% of cases), it appears that large confluent drusen formation and hyperpigmentation (presumably dysfunction in RPE) are the initial insult and the resorption of these drusen and loss of RPE (hypopigmentation) can be predictive for progression of geographic atrophy (GA). The death and dysfunction of photoreceptors and CC appear to be secondary events to loss in RPE. In neovascular AMD (~10-15% of cases), the loss of choroidal vasculature may be the initial insult to the complex. Loss of CC with an intact RPE monolayer in wet AMD has been observed. This may be due to reduction in blood supply because of large vessel stenosis. Furthermore, the environment of the CC, basement membrane and intercapillary septa, is a proinflammatory milieu with accumulation of complement components as well as proinflammatory molecules like CRP during AMD. In this toxic milieu, CC die or become dysfunction making adjacent RPE hypoxic. These hypoxic cells then produce angiogenic substances like VEGF that stimulate growth of new vessels from CC, resulting in choroidal neovascularization (CNV). The loss of CC might also be a stimulus for drusen formation since the disposal system for retinal debris and exocytosed material from RPE would be limited. Ultimately, the photoreceptors die of lack of nutrients, leakage of serum components from the neovascularization, and scar formation. Therefore, the mutualistic symbiotic relationship within the photoreceptor/RPE/BrMb/CC complex is lost in both forms of AMD. Loss of this functionally integrated relationship results in death and dysfunction of all of the components in the complex." @default.
- W2007014682 created "2016-06-24" @default.
- W2007014682 creator A5014071864 @default.
- W2007014682 creator A5070742691 @default.
- W2007014682 date "2012-08-01" @default.
- W2007014682 modified "2023-10-14" @default.
- W2007014682 title "Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex" @default.
- W2007014682 cites W121687570 @default.
- W2007014682 cites W1501698769 @default.
- W2007014682 cites W1573363574 @default.
- W2007014682 cites W1600542667 @default.
- W2007014682 cites W180812339 @default.
- W2007014682 cites W1836215938 @default.
- W2007014682 cites W1883306593 @default.
- W2007014682 cites W1964119221 @default.
- W2007014682 cites W1964375100 @default.
- W2007014682 cites W1965404473 @default.
- W2007014682 cites W1970714860 @default.
- W2007014682 cites W1972323339 @default.
- W2007014682 cites W1972444897 @default.
- W2007014682 cites W1972582798 @default.
- W2007014682 cites W1974343663 @default.
- W2007014682 cites W1975022071 @default.
- W2007014682 cites W1976346813 @default.
- W2007014682 cites W1979750784 @default.
- W2007014682 cites W1980048976 @default.
- W2007014682 cites W1981751548 @default.
- W2007014682 cites W1983640282 @default.
- W2007014682 cites W1983873751 @default.
- W2007014682 cites W1986991414 @default.
- W2007014682 cites W1987429671 @default.
- W2007014682 cites W1988077870 @default.
- W2007014682 cites W1988410112 @default.
- W2007014682 cites W1989786814 @default.
- W2007014682 cites W1991661185 @default.
- W2007014682 cites W1992625034 @default.
- W2007014682 cites W1993397750 @default.
- W2007014682 cites W1993439014 @default.
- W2007014682 cites W1993530603 @default.
- W2007014682 cites W1994025305 @default.
- W2007014682 cites W1995004338 @default.
- W2007014682 cites W1996821302 @default.
- W2007014682 cites W1996836034 @default.
- W2007014682 cites W1996870435 @default.
- W2007014682 cites W1997819745 @default.
- W2007014682 cites W1998371838 @default.
- W2007014682 cites W1999068490 @default.
- W2007014682 cites W1999414884 @default.
- W2007014682 cites W1999864131 @default.
- W2007014682 cites W1999961827 @default.
- W2007014682 cites W2000383031 @default.
- W2007014682 cites W2000399151 @default.
- W2007014682 cites W2004542669 @default.
- W2007014682 cites W2005044790 @default.
- W2007014682 cites W2007917457 @default.
- W2007014682 cites W2008289317 @default.
- W2007014682 cites W2008965058 @default.
- W2007014682 cites W2009256817 @default.
- W2007014682 cites W2009758003 @default.
- W2007014682 cites W2012322597 @default.
- W2007014682 cites W2016584341 @default.
- W2007014682 cites W2018794435 @default.
- W2007014682 cites W2019087770 @default.
- W2007014682 cites W2021311336 @default.
- W2007014682 cites W2022084143 @default.
- W2007014682 cites W2022967445 @default.
- W2007014682 cites W2024947141 @default.
- W2007014682 cites W2025398169 @default.
- W2007014682 cites W2027707278 @default.
- W2007014682 cites W2028065796 @default.
- W2007014682 cites W2029003946 @default.
- W2007014682 cites W2029789578 @default.
- W2007014682 cites W2031084334 @default.
- W2007014682 cites W2031365186 @default.
- W2007014682 cites W2031871509 @default.
- W2007014682 cites W2034060753 @default.
- W2007014682 cites W2035032667 @default.
- W2007014682 cites W2035197993 @default.
- W2007014682 cites W2037348124 @default.
- W2007014682 cites W2037370744 @default.
- W2007014682 cites W2038937675 @default.
- W2007014682 cites W2039325329 @default.
- W2007014682 cites W2040064522 @default.
- W2007014682 cites W2043057909 @default.
- W2007014682 cites W2043522730 @default.
- W2007014682 cites W2044173407 @default.
- W2007014682 cites W2044605550 @default.
- W2007014682 cites W2046638324 @default.
- W2007014682 cites W2047142409 @default.
- W2007014682 cites W2047432057 @default.
- W2007014682 cites W2047715625 @default.
- W2007014682 cites W2047897974 @default.
- W2007014682 cites W2048706534 @default.
- W2007014682 cites W2048972865 @default.
- W2007014682 cites W2050333701 @default.
- W2007014682 cites W2051690312 @default.
- W2007014682 cites W2051775471 @default.
- W2007014682 cites W2052148300 @default.