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- W2007016990 abstract "Human bleomycin hydrolase (hBH) is a neutral cysteine protease genetically associated with increased risk for Alzheimer disease. We show here that ectopic expression of hBH in 293APPwt and CHOAPPsw cells altered the processing of amyloid precursor protein (APP) and increased significantly the release of its proteolytic fragment, β amyloid (Aβ). We also found that hBH interacted and colocalized with APP as determined by subcellular fractionation, in vitro binding assay, and confocal immunolocalization. Metabolic labeling and pulse-chase experiments showed that ectopic hBH expression increased secretion of soluble APPα/β products without changing the half-life of cellular APP. We also observed that this increased Aβ secretion was independent of hBH isoforms. Our findings suggest a regulatory role for hBH in APP processing pathways.—Lefterov, I. M., Koldamova, R. P., Lazo, J. S. Human bleomycin hydrolase regulates the secretion of amyloid precursor protein. FASEB J. 14, 1837–1847 (2000)" @default.
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- W2007016990 date "2000-09-01" @default.
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- W2007016990 title "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein" @default.
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- W2007016990 doi "https://doi.org/10.1096/fj.99-0938com" @default.
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