FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007018052> ?p ?o ?g. }

• W2007018052 endingPage "478" @default.
• W2007018052 startingPage "471" @default.
• W2007018052 abstract "NMDA receptor subunit composition varies throughout the brain, providing molecular diversity in NMDA receptor function. The NR2 subunits (NR2A-D) in large part dictate the distinct functional properties of NMDA receptors and differentially regulate receptor trafficking. Although the NR2C subunit is highly enriched in cerebellar granule cells and plays a unique role in cerebellar function, little is known about NR2C-specific regulation of NMDA receptors. Here, we demonstrate that PKB/Akt directly phosphorylates NR2C on serine 1096 (S1096). In addition, we identify 14-3-3epsilon as an NR2C interactor, whose binding is dependent on S1096 phosphorylation. Both growth factor stimulation and NMDA receptor activity lead to a robust increase in both phosphorylation of NR2C on S1096 and surface expression of cerebellar NMDA receptors. Finally, we find that NR2C expression, unlike NR2A and NR2B, supports neuronal survival. Thus, our data provide a direct mechanistic link between growth factor stimulation and regulation of cerebellar NMDA receptors." @default.
• W2007018052 created "2016-06-24" @default.
• W2007018052 creator A5007550022 @default.
• W2007018052 creator A5071397864 @default.
• W2007018052 date "2009-05-01" @default.
• W2007018052 modified "2023-10-01" @default.
• W2007018052 title "Growth Factor-Dependent Trafficking of Cerebellar NMDA Receptors via Protein Kinase B/Akt Phosphorylation of NR2C" @default.
• W2007018052 cites W1507667128 @default.
• W2007018052 cites W1518401857 @default.
• W2007018052 cites W1551983009 @default.
• W2007018052 cites W1586088169 @default.
• W2007018052 cites W1603191004 @default.
• W2007018052 cites W1966673980 @default.
• W2007018052 cites W1970851711 @default.
• W2007018052 cites W1971335269 @default.
• W2007018052 cites W1977146061 @default.
• W2007018052 cites W1983031627 @default.
• W2007018052 cites W1985241009 @default.
• W2007018052 cites W2008796590 @default.
• W2007018052 cites W2009942449 @default.
• W2007018052 cites W2014096411 @default.
• W2007018052 cites W2017882961 @default.
• W2007018052 cites W2030126027 @default.
• W2007018052 cites W2037863613 @default.
• W2007018052 cites W2045895646 @default.
• W2007018052 cites W2048121649 @default.
• W2007018052 cites W2051909860 @default.
• W2007018052 cites W2058459224 @default.
• W2007018052 cites W2059040821 @default.
• W2007018052 cites W2065169750 @default.
• W2007018052 cites W2069512007 @default.
• W2007018052 cites W2071075259 @default.
• W2007018052 cites W2072529095 @default.
• W2007018052 cites W2078167209 @default.
• W2007018052 cites W2086107539 @default.
• W2007018052 cites W2086329101 @default.
• W2007018052 cites W2094212507 @default.
• W2007018052 cites W2102527735 @default.
• W2007018052 cites W2112009693 @default.
• W2007018052 cites W2123852291 @default.
• W2007018052 cites W2129839751 @default.
• W2007018052 cites W2131426434 @default.
• W2007018052 cites W2131958615 @default.
• W2007018052 cites W2133469434 @default.
• W2007018052 cites W2147114673 @default.
• W2007018052 cites W2148365115 @default.
• W2007018052 cites W2152541148 @default.
• W2007018052 cites W2155515046 @default.
• W2007018052 cites W2156945415 @default.
• W2007018052 doi "https://doi.org/10.1016/j.neuron.2009.04.015" @default.
• W2007018052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2716006" @default.
• W2007018052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19477150" @default.
• W2007018052 hasPublicationYear "2009" @default.
• W2007018052 type Work @default.
• W2007018052 sameAs 2007018052 @default.
• W2007018052 citedByCount "65" @default.
• W2007018052 countsByYear W20070180522012 @default.
• W2007018052 countsByYear W20070180522013 @default.
• W2007018052 countsByYear W20070180522014 @default.
• W2007018052 countsByYear W20070180522015 @default.
• W2007018052 countsByYear W20070180522016 @default.
• W2007018052 countsByYear W20070180522017 @default.
• W2007018052 countsByYear W20070180522018 @default.
• W2007018052 countsByYear W20070180522019 @default.
• W2007018052 countsByYear W20070180522020 @default.
• W2007018052 countsByYear W20070180522021 @default.
• W2007018052 countsByYear W20070180522022 @default.
• W2007018052 countsByYear W20070180522023 @default.
• W2007018052 crossrefType "journal-article" @default.
• W2007018052 hasAuthorship W2007018052A5007550022 @default.
• W2007018052 hasAuthorship W2007018052A5071397864 @default.
• W2007018052 hasBestOaLocation W20070180521 @default.
• W2007018052 hasConcept C104292427 @default.
• W2007018052 hasConcept C104317684 @default.
• W2007018052 hasConcept C11960822 @default.
• W2007018052 hasConcept C169760540 @default.
• W2007018052 hasConcept C170493617 @default.
• W2007018052 hasConcept C185592680 @default.
• W2007018052 hasConcept C2776414213 @default.
• W2007018052 hasConcept C2779652256 @default.
• W2007018052 hasConcept C55493867 @default.
• W2007018052 hasConcept C67018056 @default.
• W2007018052 hasConcept C86803240 @default.
• W2007018052 hasConcept C95444343 @default.
• W2007018052 hasConceptScore W2007018052C104292427 @default.
• W2007018052 hasConceptScore W2007018052C104317684 @default.
• W2007018052 hasConceptScore W2007018052C11960822 @default.
• W2007018052 hasConceptScore W2007018052C169760540 @default.
• W2007018052 hasConceptScore W2007018052C170493617 @default.
• W2007018052 hasConceptScore W2007018052C185592680 @default.
• W2007018052 hasConceptScore W2007018052C2776414213 @default.
• W2007018052 hasConceptScore W2007018052C2779652256 @default.
• W2007018052 hasConceptScore W2007018052C55493867 @default.
• W2007018052 hasConceptScore W2007018052C67018056 @default.
• W2007018052 hasConceptScore W2007018052C86803240 @default.
• W2007018052 hasConceptScore W2007018052C95444343 @default.
• W2007018052 hasIssue "4" @default.
• W2007018052 hasLocation W20070180521 @default.

• next