FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007024043> ?p ?o ?g. }

• W2007024043 endingPage "e0120099" @default.
• W2007024043 startingPage "e0120099" @default.
• W2007024043 abstract "The precursors of atherogenic dyslipidemia (AD) are not well defined. Therefore, we investigated 62 non-obese, non-diabetic AD and 221 normolipemic children. Anthropometric parameters, blood pressure and biochemical measures were obtained in index children, their parents and all available siblings. The heritability (h2) of anthropometric and biochemical traits was estimated by SOLAR. Rare and common variants in APOA1 and LPL genes were screened by re-sequencing. Compared to normolipemic, AD children showed increased body mass index, waist circumference, plasma glucose, insulin, ApoB, HOMA-IR, hs-CRP and lower adiponectin (p<0.001 for all). Metabolic syndrome was present in 40% of AD while absent in controls. All traits (except adiponectin and hs-CRP) showed a strong familial aggregation, with plasma glucose having the highest heritability (89%). Overall, 4 LPL loss-of-function mutations were detected (p.Asp9Asn, p.Ser45Asn, p.Asn291Ser, p.Leu365Val) and their cumulative prevalence was higher in AD than in control children (0.073 vs. 0.026; P=0.038). The LPL p.S447* gain-of-function mutation, resulted to be less frequent in AD than in control children (0.064 vs. 0.126; P=0.082). No variant in the APOA1 gene was found. Our data indicate that AD is a rather common dyslipidemia in childhood; it associates with metabolic abnormalities typical of insulin resistant state and shows a strong familial aggregation. LPL variants may contribute to the development of AD phenotype." @default.
• W2007024043 created "2016-06-24" @default.
• W2007024043 creator A5024394361 @default.
• W2007024043 creator A5032379642 @default.
• W2007024043 creator A5035489654 @default.
• W2007024043 creator A5036018996 @default.
• W2007024043 creator A5037315413 @default.
• W2007024043 creator A5062154791 @default.
• W2007024043 creator A5071915147 @default.
• W2007024043 creator A5073298026 @default.
• W2007024043 creator A5073413016 @default.
• W2007024043 creator A5077173779 @default.
• W2007024043 creator A5083451515 @default.
• W2007024043 creator A5083981268 @default.
• W2007024043 date "2015-04-21" @default.
• W2007024043 modified "2023-09-27" @default.
• W2007024043 title "Atherogenic Dyslipidemia in Children: Evaluation of Clinical, Biochemical and Genetic Aspects" @default.
• W2007024043 cites W1807577609 @default.
• W2007024043 cites W1972353334 @default.
• W2007024043 cites W1972922499 @default.
• W2007024043 cites W1973110938 @default.
• W2007024043 cites W1976810482 @default.
• W2007024043 cites W1984299205 @default.
• W2007024043 cites W1994181405 @default.
• W2007024043 cites W1995915856 @default.
• W2007024043 cites W2001459906 @default.
• W2007024043 cites W2004070982 @default.
• W2007024043 cites W2014232335 @default.
• W2007024043 cites W2021055729 @default.
• W2007024043 cites W2024591092 @default.
• W2007024043 cites W2039290641 @default.
• W2007024043 cites W2042140336 @default.
• W2007024043 cites W2052740563 @default.
• W2007024043 cites W2076395750 @default.
• W2007024043 cites W2079550470 @default.
• W2007024043 cites W2081825726 @default.
• W2007024043 cites W2083454724 @default.
• W2007024043 cites W2090909399 @default.
• W2007024043 cites W2112582775 @default.
• W2007024043 cites W2115335486 @default.
• W2007024043 cites W2117219849 @default.
• W2007024043 cites W2118094114 @default.
• W2007024043 cites W2118676558 @default.
• W2007024043 cites W2121528778 @default.
• W2007024043 cites W2123289485 @default.
• W2007024043 cites W2126319951 @default.
• W2007024043 cites W2128869451 @default.
• W2007024043 cites W2160234571 @default.
• W2007024043 cites W2169911638 @default.
• W2007024043 cites W2171233936 @default.
• W2007024043 cites W2314164263 @default.
• W2007024043 cites W2466242287 @default.
• W2007024043 cites W2607031541 @default.
• W2007024043 doi "https://doi.org/10.1371/journal.pone.0120099" @default.
• W2007024043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4405441" @default.
• W2007024043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25897955" @default.
• W2007024043 hasPublicationYear "2015" @default.
• W2007024043 type Work @default.
• W2007024043 sameAs 2007024043 @default.
• W2007024043 citedByCount "12" @default.
• W2007024043 countsByYear W20070240432015 @default.
• W2007024043 countsByYear W20070240432016 @default.
• W2007024043 countsByYear W20070240432017 @default.
• W2007024043 countsByYear W20070240432019 @default.
• W2007024043 countsByYear W20070240432021 @default.
• W2007024043 countsByYear W20070240432023 @default.
• W2007024043 crossrefType "journal-article" @default.
• W2007024043 hasAuthorship W2007024043A5024394361 @default.
• W2007024043 hasAuthorship W2007024043A5032379642 @default.
• W2007024043 hasAuthorship W2007024043A5035489654 @default.
• W2007024043 hasAuthorship W2007024043A5036018996 @default.
• W2007024043 hasAuthorship W2007024043A5037315413 @default.
• W2007024043 hasAuthorship W2007024043A5062154791 @default.
• W2007024043 hasAuthorship W2007024043A5071915147 @default.
• W2007024043 hasAuthorship W2007024043A5073298026 @default.
• W2007024043 hasAuthorship W2007024043A5073413016 @default.
• W2007024043 hasAuthorship W2007024043A5077173779 @default.
• W2007024043 hasAuthorship W2007024043A5083451515 @default.
• W2007024043 hasAuthorship W2007024043A5083981268 @default.
• W2007024043 hasBestOaLocation W20070240431 @default.
• W2007024043 hasConcept C126322002 @default.
• W2007024043 hasConcept C134018914 @default.
• W2007024043 hasConcept C161890455 @default.
• W2007024043 hasConcept C2776193436 @default.
• W2007024043 hasConcept C2776782570 @default.
• W2007024043 hasConcept C2777391703 @default.
• W2007024043 hasConcept C2778096610 @default.
• W2007024043 hasConcept C2778163477 @default.
• W2007024043 hasConcept C2780221984 @default.
• W2007024043 hasConcept C2780578515 @default.
• W2007024043 hasConcept C511355011 @default.
• W2007024043 hasConcept C54355233 @default.
• W2007024043 hasConcept C62746215 @default.
• W2007024043 hasConcept C71924100 @default.
• W2007024043 hasConcept C86803240 @default.
• W2007024043 hasConceptScore W2007024043C126322002 @default.
• W2007024043 hasConceptScore W2007024043C134018914 @default.
• W2007024043 hasConceptScore W2007024043C161890455 @default.

• next