Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007024162> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2007024162 endingPage "171" @default.
- W2007024162 startingPage "163" @default.
- W2007024162 abstract "The detection and quantification of alternate polymorphs of active pharmaceutical ingredients (APIs), particularly at low concentrations is a key issue for the manufacture and analysis of solid-state formulations. Each polymorph can possess unique physical and chemical properties which in turn can directly affect factors such as solubility and bioavailability. Near infra-red (NIR) and Raman spectroscopies can be used for the rapid characterisation and quantification of polymorphs in solid samples. In this study we have generated a model tablet system with two excipients and a 10% API concentration, where the API is a mixture of the FII and FIII polymorphs of piracetam. Using transmission Raman spectroscopy (TRS) and NIR spectroscopy it was possible to detect FII polymorph contamination in these model tablets with limits of detection (LODs) of 0.6 and 0.7%, respectively, with respect to the total tablet weight (or ∼6-7% of the API content). The TRS method is the superior method because of the speed of analysis (∼6s per sample), better sampling statistics, and because the sharper, more resolved bands in the Raman spectra allowed for easier interpretation of the spectral data. In addition the TRS used here provides facile access to the low frequency wavenumber region for analysis of solid-state lattice modes." @default.
- W2007024162 created "2016-06-24" @default.
- W2007024162 creator A5015054533 @default.
- W2007024162 creator A5080028742 @default.
- W2007024162 date "2013-01-01" @default.
- W2007024162 modified "2023-10-01" @default.
- W2007024162 title "Quantitative polymorph contaminant analysis in tablets using Raman and near infra-red spectroscopies" @default.
- W2007024162 cites W1580142972 @default.
- W2007024162 cites W1970304592 @default.
- W2007024162 cites W1970874008 @default.
- W2007024162 cites W1991158443 @default.
- W2007024162 cites W1991957603 @default.
- W2007024162 cites W1992032473 @default.
- W2007024162 cites W1992380940 @default.
- W2007024162 cites W1993880806 @default.
- W2007024162 cites W1997032397 @default.
- W2007024162 cites W2005703923 @default.
- W2007024162 cites W2006568582 @default.
- W2007024162 cites W2009712464 @default.
- W2007024162 cites W2012032202 @default.
- W2007024162 cites W2015254952 @default.
- W2007024162 cites W2017954333 @default.
- W2007024162 cites W2049274132 @default.
- W2007024162 cites W2061388384 @default.
- W2007024162 cites W2064523191 @default.
- W2007024162 cites W2065431130 @default.
- W2007024162 cites W2068695414 @default.
- W2007024162 cites W2069794408 @default.
- W2007024162 cites W2075035035 @default.
- W2007024162 cites W2085522882 @default.
- W2007024162 cites W2100458127 @default.
- W2007024162 cites W2111950072 @default.
- W2007024162 cites W2117495440 @default.
- W2007024162 cites W2122877923 @default.
- W2007024162 cites W4230831096 @default.
- W2007024162 doi "https://doi.org/10.1016/j.jpba.2012.10.002" @default.
- W2007024162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23146243" @default.
- W2007024162 hasPublicationYear "2013" @default.
- W2007024162 type Work @default.
- W2007024162 sameAs 2007024162 @default.
- W2007024162 citedByCount "59" @default.
- W2007024162 countsByYear W20070241622013 @default.
- W2007024162 countsByYear W20070241622014 @default.
- W2007024162 countsByYear W20070241622015 @default.
- W2007024162 countsByYear W20070241622016 @default.
- W2007024162 countsByYear W20070241622017 @default.
- W2007024162 countsByYear W20070241622018 @default.
- W2007024162 countsByYear W20070241622019 @default.
- W2007024162 countsByYear W20070241622020 @default.
- W2007024162 countsByYear W20070241622021 @default.
- W2007024162 countsByYear W20070241622022 @default.
- W2007024162 countsByYear W20070241622023 @default.
- W2007024162 crossrefType "journal-article" @default.
- W2007024162 hasAuthorship W2007024162A5015054533 @default.
- W2007024162 hasAuthorship W2007024162A5080028742 @default.
- W2007024162 hasBestOaLocation W20070241622 @default.
- W2007024162 hasConcept C107814960 @default.
- W2007024162 hasConcept C113196181 @default.
- W2007024162 hasConcept C120665830 @default.
- W2007024162 hasConcept C121332964 @default.
- W2007024162 hasConcept C147789679 @default.
- W2007024162 hasConcept C155574463 @default.
- W2007024162 hasConcept C185592680 @default.
- W2007024162 hasConcept C32891209 @default.
- W2007024162 hasConcept C40003534 @default.
- W2007024162 hasConcept C43617362 @default.
- W2007024162 hasConcept C62520636 @default.
- W2007024162 hasConceptScore W2007024162C107814960 @default.
- W2007024162 hasConceptScore W2007024162C113196181 @default.
- W2007024162 hasConceptScore W2007024162C120665830 @default.
- W2007024162 hasConceptScore W2007024162C121332964 @default.
- W2007024162 hasConceptScore W2007024162C147789679 @default.
- W2007024162 hasConceptScore W2007024162C155574463 @default.
- W2007024162 hasConceptScore W2007024162C185592680 @default.
- W2007024162 hasConceptScore W2007024162C32891209 @default.
- W2007024162 hasConceptScore W2007024162C40003534 @default.
- W2007024162 hasConceptScore W2007024162C43617362 @default.
- W2007024162 hasConceptScore W2007024162C62520636 @default.
- W2007024162 hasLocation W20070241621 @default.
- W2007024162 hasLocation W20070241622 @default.
- W2007024162 hasLocation W20070241623 @default.
- W2007024162 hasOpenAccess W2007024162 @default.
- W2007024162 hasPrimaryLocation W20070241621 @default.
- W2007024162 hasRelatedWork W1970954876 @default.
- W2007024162 hasRelatedWork W1974818739 @default.
- W2007024162 hasRelatedWork W1986101966 @default.
- W2007024162 hasRelatedWork W2018136682 @default.
- W2007024162 hasRelatedWork W2058864804 @default.
- W2007024162 hasRelatedWork W2083662438 @default.
- W2007024162 hasRelatedWork W2086885043 @default.
- W2007024162 hasRelatedWork W2152522044 @default.
- W2007024162 hasRelatedWork W2327853851 @default.
- W2007024162 hasRelatedWork W2952083759 @default.
- W2007024162 hasVolume "72" @default.
- W2007024162 isParatext "false" @default.
- W2007024162 isRetracted "false" @default.
- W2007024162 magId "2007024162" @default.
- W2007024162 workType "article" @default.