Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007024562> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2007024562 endingPage "500" @default.
- W2007024562 startingPage "491" @default.
- W2007024562 abstract "Trichosanthin (TCS) is a type-I ribosome-inactivating protein (RIP) with wide spectrum of biological and pharmacological activities. In the present study, a potential site on the TCS molecule (position 120-123) is identified which may be important for the biological activities of TCS. By using site-directed mutagenesis, position 120-123 of TCS was either deleted or changed from Lys-Ile-Arg-Glu (hydrophilic) to Ser-Ala-Gly-Gly (hydrophobic). Deletion of these residues rendered a TCS molecule completely deprived of ribosome inactivating activity, while hydrophobic replacement caused 4000-fold decrease in ribosome inactivating activity. The abortifacient activity of these two mutants was retained with decreased potency. This implies that position 120-123 of the native TCS molecule plays a critical role in maintaining its biological activity." @default.
- W2007024562 created "2016-06-24" @default.
- W2007024562 creator A5000796650 @default.
- W2007024562 creator A5023230164 @default.
- W2007024562 creator A5023899800 @default.
- W2007024562 creator A5024049257 @default.
- W2007024562 creator A5028926069 @default.
- W2007024562 creator A5066596938 @default.
- W2007024562 creator A5087653918 @default.
- W2007024562 date "1998-01-01" @default.
- W2007024562 modified "2023-09-27" @default.
- W2007024562 title "Position 120–123, a potential active site of trichosanthin" @default.
- W2007024562 cites W1754467696 @default.
- W2007024562 cites W1754967718 @default.
- W2007024562 cites W1873199501 @default.
- W2007024562 cites W1964653451 @default.
- W2007024562 cites W1969443511 @default.
- W2007024562 cites W1970403529 @default.
- W2007024562 cites W1987334410 @default.
- W2007024562 cites W2005111415 @default.
- W2007024562 cites W2014097133 @default.
- W2007024562 cites W2014179710 @default.
- W2007024562 cites W2019032278 @default.
- W2007024562 cites W2026301672 @default.
- W2007024562 cites W2027683913 @default.
- W2007024562 cites W2043202382 @default.
- W2007024562 cites W2048611380 @default.
- W2007024562 cites W2077672251 @default.
- W2007024562 cites W2088522360 @default.
- W2007024562 cites W2156490420 @default.
- W2007024562 doi "https://doi.org/10.1016/s0024-3205(97)01145-4" @default.
- W2007024562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9464461" @default.
- W2007024562 hasPublicationYear "1998" @default.
- W2007024562 type Work @default.
- W2007024562 sameAs 2007024562 @default.
- W2007024562 citedByCount "13" @default.
- W2007024562 countsByYear W20070245622012 @default.
- W2007024562 countsByYear W20070245622018 @default.
- W2007024562 crossrefType "journal-article" @default.
- W2007024562 hasAuthorship W2007024562A5000796650 @default.
- W2007024562 hasAuthorship W2007024562A5023230164 @default.
- W2007024562 hasAuthorship W2007024562A5023899800 @default.
- W2007024562 hasAuthorship W2007024562A5024049257 @default.
- W2007024562 hasAuthorship W2007024562A5028926069 @default.
- W2007024562 hasAuthorship W2007024562A5066596938 @default.
- W2007024562 hasAuthorship W2007024562A5087653918 @default.
- W2007024562 hasConcept C103408237 @default.
- W2007024562 hasConcept C104317684 @default.
- W2007024562 hasConcept C107824862 @default.
- W2007024562 hasConcept C116073593 @default.
- W2007024562 hasConcept C143065580 @default.
- W2007024562 hasConcept C16318435 @default.
- W2007024562 hasConcept C185592680 @default.
- W2007024562 hasConcept C202751555 @default.
- W2007024562 hasConcept C2776624327 @default.
- W2007024562 hasConcept C2780128948 @default.
- W2007024562 hasConcept C55493867 @default.
- W2007024562 hasConcept C67705224 @default.
- W2007024562 hasConcept C88478588 @default.
- W2007024562 hasConcept C96267730 @default.
- W2007024562 hasConceptScore W2007024562C103408237 @default.
- W2007024562 hasConceptScore W2007024562C104317684 @default.
- W2007024562 hasConceptScore W2007024562C107824862 @default.
- W2007024562 hasConceptScore W2007024562C116073593 @default.
- W2007024562 hasConceptScore W2007024562C143065580 @default.
- W2007024562 hasConceptScore W2007024562C16318435 @default.
- W2007024562 hasConceptScore W2007024562C185592680 @default.
- W2007024562 hasConceptScore W2007024562C202751555 @default.
- W2007024562 hasConceptScore W2007024562C2776624327 @default.
- W2007024562 hasConceptScore W2007024562C2780128948 @default.
- W2007024562 hasConceptScore W2007024562C55493867 @default.
- W2007024562 hasConceptScore W2007024562C67705224 @default.
- W2007024562 hasConceptScore W2007024562C88478588 @default.
- W2007024562 hasConceptScore W2007024562C96267730 @default.
- W2007024562 hasIssue "6" @default.
- W2007024562 hasLocation W20070245621 @default.
- W2007024562 hasLocation W20070245622 @default.
- W2007024562 hasOpenAccess W2007024562 @default.
- W2007024562 hasPrimaryLocation W20070245621 @default.
- W2007024562 hasRelatedWork W1998025498 @default.
- W2007024562 hasRelatedWork W2002749969 @default.
- W2007024562 hasRelatedWork W2007024562 @default.
- W2007024562 hasRelatedWork W2007645086 @default.
- W2007024562 hasRelatedWork W2091064370 @default.
- W2007024562 hasRelatedWork W2380586162 @default.
- W2007024562 hasRelatedWork W2414386040 @default.
- W2007024562 hasRelatedWork W2556797940 @default.
- W2007024562 hasRelatedWork W2888282232 @default.
- W2007024562 hasRelatedWork W2891277551 @default.
- W2007024562 hasVolume "62" @default.
- W2007024562 isParatext "false" @default.
- W2007024562 isRetracted "false" @default.
- W2007024562 magId "2007024562" @default.
- W2007024562 workType "article" @default.