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• W2007029597 abstract "background This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single dose or a multiple-dose regimen (until the lines/ drain tubes were removed, but not for more than 5 days). methods Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20). results The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence interval = −1.02 to 3.92). conclusions A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery." @default.
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• W2007029597 date "1998-02-01" @default.
• W2007029597 modified "2023-10-06" @default.
• W2007029597 title "Duration of antimicrobial prophylaxis in vascular surgery" @default.
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• W2007029597 doi "https://doi.org/10.1016/s0002-9610(97)00270-5" @default.
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