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• W2007029625 abstract "The behavioural effect of intrastriatally injected cholecystokinin sulphated octapeptide (CCK-8S), and its interactions with the antagonists Z-CCK-(27-32)NH2 and proglumide, were investigated in mice. When injected into the right striatum, CCK-8S(0.05–1 ng) induced contralateral rotations, as did the dopamine agonist apomorphine. Non-sulphated CCK-8 was inactive and sulphated desamino-CCK-7 was only weakly active in this respect. CCK-8S-induced turning was antagonized by co-injected Z-CCK-(27-32)NH2 (0.01–10 ng) or proglumide (0.1–1 μg), as well as by intraperitoneal injection of the neuroleptic drug haloperidol. These data suggest that CCK-8S may, in these conditions, stimulate dopamine-mediated neurotransmission, and that Z-CCK-(27-32)NH2, in addition to its peripheral effect, is also a very potent CCK antagonist at the striatal level." @default.
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• W2007029625 date "1986-03-01" @default.
• W2007029625 modified "2023-10-16" @default.
• W2007029625 title "Evidence for dopaminomimetic effect of intrastriatally injected cholecystokinin octapeptide in mice" @default.
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• W2007029625 doi "https://doi.org/10.1016/0014-2999(86)90260-8" @default.
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