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• W2007030768 abstract "Paraffin sections and more than 7,000 plastic cross‐sections of temporal arteries from 27 patients with a clinical diagnosis of polymyalgia rheumatica (PMR), 16 patients with a clinical diagnosis of temporal arteritis (TA) and 18 age‐ and sex‐matched postmortem controls were studied using light microscopy. A new method was developed to permit a morphometric comparison between biopsies and autopsy specimens. Two stages of inflammation were discerned in TA. In atrophic arterial segments there was a focal, foreign‐body, giant‐cell reaction to the calcified internal elastic membrane (IEM) with a spatially correlated, mononuclear cell infiltration. Isolated giant cells were also found to attack the IEM in these cases. The majority of the biopsies displayed a different picture with a diffuse macrophage attack on media and intima with numerous and apparently macrophage‐derived giant cells, which did not attack calcifications. The latter arteries were significantly widened (p < 0.02), which indicates that this phase is the later one. Non‐inflamed segments of PMR vessels displayed a significant, non‐reactive media atrophy compared with controls (p < 0.03) and their IEM calcifications were significantly larger (p < 0.02). The circumference was smaller in atrophic PMR arteries than in inflamed TA arteries (p < 0.006), which contradicts post‐inflammatory scarring." @default.
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• W2007030768 date "1991-07-01" @default.
• W2007030768 modified "2023-10-05" @default.
• W2007030768 title "Temporal artery morphology and morphometry in giant cell arteritis" @default.
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• W2007030768 doi "https://doi.org/10.1111/j.1699-0463.1991.tb01294.x" @default.
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