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• W2007033110 abstract "The effects of nine neuropeptides on the uptake and release of 3H-dopamine (DA) were studied in slices of rat striatum. Superfusion of preloaded slices at room temperature gave a steady release of 3H-DA after 30 min. Repetitive depolarisation with 20 mM K+ evoked pronounced, calcium-dependent releases of 3H-DA which declined exponentially. Substance P (SP), neurotensin and somatostatin all actively released 3H-DA, whilst cholecystokinin octapeptide (CCK), luteinising hormone releasing hormone (LHRH), thyrotrophin releasing hormone (TRH), adrenocorticotrophin (ACTH), vasopressin and oxytocin were without effect on spontaneous 3H-DA efflux. The effects of the peptides on K+-induced 3H-DA overflow were more varied; neurotensin, TRH and ACTH had no effect, whereas CCK, somatostatin and LHRH potentiated and SP, vasopressin and oxytocin attenuated 3H-DA release. None of the peptides altered the uptake of 3H-DA at the concentrations which modified its release (0.1–10 μM). It is suggested that modulating DA release may be fundamental to the central actions of these substances in the intact animal." @default.
• W2007033110 created "2016-06-24" @default.
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• W2007033110 date "1982-01-01" @default.
• W2007033110 modified "2023-09-28" @default.
• W2007033110 title "Influence of peptides on 3H-dopamine release from superfused rat striatal slices" @default.
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• W2007033110 doi "https://doi.org/10.1016/0197-0186(82)90059-6" @default.
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