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• W2007037349 abstract "<b>Objective: </b> To determine if excessive daytime sleepiness (EDS) can predate future Parkinson disease (PD). <b>Methods: </b> EDS was assessed in 3,078 men aged 71 to 93 years in the Honolulu-Asia Aging Study from 1991 to 1993. All were free of prevalent PD and dementia. Follow-up for incident PD was based on three repeat neurologic assessments from 1994 to 2001. <b>Results: </b> During the course of follow-up, 43 men developed PD (19.9/10,000 person-years). After age adjustment, there was more than a threefold excess in the risk of PD in men with EDS vs men without EDS (55.3 vs 17.0/10,000 person-years; odds ratio [OR] = 3.3; 95% CI = 1.4 to 7.0; <i>p</i> = 0.004). Additional adjustment for insomnia, cognitive function, depressed mood, midlife cigarette smoking and coffee drinking, and other factors failed to alter the association between EDS and PD (OR = 2.8; 95% CI = 1.1 to 6.4; <i>p</i> = 0.014). Other sleep related features such as insomnia, daytime napping, early morning grogginess, and frequent nocturnal awakening showed little relation with the risk of PD. <b>Conclusions: </b> Excessive daytime sleepiness may be associated with an increased risk of developing Parkinson disease." @default.
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• W2007037349 date "2005-11-07" @default.
• W2007037349 modified "2023-10-12" @default.
• W2007037349 title "Excessive daytime sleepiness and subsequent development of Parkinson disease" @default.
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• W2007037349 doi "https://doi.org/10.1212/01.wnl.0000183056.89590.0d" @default.
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